Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5

Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5

Follicular helper T (TFH) cells promote germinal centre (GC) response for efficient generation of protective antibodies during humoral immunity. Here the authors show that deficiency of the translational repressor, Capicua/CIC, enhances TFH differentiation and GC responses potentially via the derepr...

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Auteurs principaux: Sungjun Park, Seungwon Lee, Choong-Gu Lee, Guk Yeol Park, Hyebeen Hong, Jeon-Soo Lee, Young Min Kim, Sung Bae Lee, Daehee Hwang, Youn Soo Choi, John D. Fryer, Sin-Hyeog Im, Seung-Woo Lee, Yoontae Lee
Format: article
Langue:EN
Publié: Nature Portfolio 2017
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/b60b97a6a56040e89b56ef95ec263afc
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