Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility
Defining robust, penetrant synthetic lethal targets for cancer therapeutics is a challenge. Here, the authors demonstrate how pathway, genetic and cellular context dictates dependence on cancer targets.
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| Main Authors: | , , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2020
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| Subjects: | |
| Online Access: | https://doaj.org/article/b6264ed197d149c5a5e05804786dbdb6 |
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