Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility

Defining robust, penetrant synthetic lethal targets for cancer therapeutics is a challenge. Here, the authors demonstrate how pathway, genetic and cellular context dictates dependence on cancer targets.

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Main Authors:	Angel A. Ku, Hsien-Ming Hu, Xin Zhao, Khyati N. Shah, Sameera Kongara, Di Wu, Frank McCormick, Allan Balmain, Sourav Bandyopadhyay
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/b6264ed197d149c5a5e05804786dbdb6
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spelling	oai:doaj.org-article:b6264ed197d149c5a5e05804786dbdb62021-12-02T16:50:26ZIntegration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility10.1038/s41467-020-16078-y2041-1723https://doaj.org/article/b6264ed197d149c5a5e05804786dbdb62020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16078-yhttps://doaj.org/toc/2041-1723Defining robust, penetrant synthetic lethal targets for cancer therapeutics is a challenge. Here, the authors demonstrate how pathway, genetic and cellular context dictates dependence on cancer targets.Angel A. KuHsien-Ming HuXin ZhaoKhyati N. ShahSameera KongaraDi WuFrank McCormickAllan BalmainSourav BandyopadhyayNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Angel A. Ku Hsien-Ming Hu Xin Zhao Khyati N. Shah Sameera Kongara Di Wu Frank McCormick Allan Balmain Sourav Bandyopadhyay Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility
description	Defining robust, penetrant synthetic lethal targets for cancer therapeutics is a challenge. Here, the authors demonstrate how pathway, genetic and cellular context dictates dependence on cancer targets.
format	article
author	Angel A. Ku Hsien-Ming Hu Xin Zhao Khyati N. Shah Sameera Kongara Di Wu Frank McCormick Allan Balmain Sourav Bandyopadhyay
author_facet	Angel A. Ku Hsien-Ming Hu Xin Zhao Khyati N. Shah Sameera Kongara Di Wu Frank McCormick Allan Balmain Sourav Bandyopadhyay
author_sort	Angel A. Ku
title	Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility
title_short	Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility
title_full	Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility
title_fullStr	Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility
title_full_unstemmed	Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility
title_sort	integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b6264ed197d149c5a5e05804786dbdb6
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Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility

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