Tocilizumab reduces COVID-19 mortality and pathology in a dose and timing-dependent fashion: a multi-centric study

Tocilizumab reduces COVID-19 mortality and pathology in a dose and timing-dependent fashion: a multi-centric study

Abstract Life-threatening COVID-19 is associated with strong inflammation, where an IL-6-driven cytokine storm appears to be a cornerstone for enhanced pathology. Nonetheless, the specific inhibition of such pathway has shown mixed outcomes. This could be due to variations in the dose of tocilizumab...

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Main Authors: Alejandro Durán-Méndez, Alma Delia Aguilar-Arroyo, Emiliano Vivanco-Gómez, Eduardo Nieto-Ortega, Daniela Pérez-Ortega, Cristian Jiménez-Pérez, Karla Y. Hernández-Skewes, Guillermo Montiel-Bravo, Oscar J. Roque-Reyes, Fernanda Romero-Lechuga, Diana Medina-Santos, Perla Oriana-Román, Jorge Rafael Flores-Hernández, Juan Daniel Méndez-Coca, Daniela Montaño-Olmos, Karla Cecilia Farfán-Lazos, Miranda Tobón-Cubillos, América Viveros-Hernández, Fernando Sevilla-Castillo, Ángel Raúl Hernández-Romero, Shannat Ortega-Rodríguez, Aldo Christiaan Jardínez-Vera, María Antonieta Solís-González, Antonio Ramos de la Medina, Laura Martínez Pérez-Maldonado, Elizabeth Lagunes-Lara, Miguel Cova-Bonilla, Alberto N. Peón
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/b632d86dac4740a59ca6312d3f6f933f
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https://doaj.org/article/b632d86dac4740a59ca6312d3f6f933f

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