Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins

RaPID (Random non-standard Peptides Integrated Discovery) enables discovery of small macrocyclic peptides binding desired targets. Here, the authors propose lasso-grafting: the RaPID-derived peptides are implanted onto diverse proteins and maintain both the binding properties of the cyclic peptide a...

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Autores principales:	Emiko Mihara, Satoshi Watanabe, Nasir K. Bashiruddin, Nozomi Nakamura, Kyoko Matoba, Yumi Sano, Rumit Maini, Yizhen Yin, Katsuya Sakai, Takao Arimori, Kunio Matsumoto, Hiroaki Suga, Junichi Takagi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6402a431ea3401381e2112d57500bf8
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spelling	oai:doaj.org-article:b6402a431ea3401381e2112d57500bf82021-12-02T13:14:48ZLasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins10.1038/s41467-021-21875-02041-1723https://doaj.org/article/b6402a431ea3401381e2112d57500bf82021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21875-0https://doaj.org/toc/2041-1723RaPID (Random non-standard Peptides Integrated Discovery) enables discovery of small macrocyclic peptides binding desired targets. Here, the authors propose lasso-grafting: the RaPID-derived peptides are implanted onto diverse proteins and maintain both the binding properties of the cyclic peptide and the host protein function.Emiko MiharaSatoshi WatanabeNasir K. BashiruddinNozomi NakamuraKyoko MatobaYumi SanoRumit MainiYizhen YinKatsuya SakaiTakao ArimoriKunio MatsumotoHiroaki SugaJunichi TakagiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emiko Mihara Satoshi Watanabe Nasir K. Bashiruddin Nozomi Nakamura Kyoko Matoba Yumi Sano Rumit Maini Yizhen Yin Katsuya Sakai Takao Arimori Kunio Matsumoto Hiroaki Suga Junichi Takagi Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins
description	RaPID (Random non-standard Peptides Integrated Discovery) enables discovery of small macrocyclic peptides binding desired targets. Here, the authors propose lasso-grafting: the RaPID-derived peptides are implanted onto diverse proteins and maintain both the binding properties of the cyclic peptide and the host protein function.
format	article
author	Emiko Mihara Satoshi Watanabe Nasir K. Bashiruddin Nozomi Nakamura Kyoko Matoba Yumi Sano Rumit Maini Yizhen Yin Katsuya Sakai Takao Arimori Kunio Matsumoto Hiroaki Suga Junichi Takagi
author_facet	Emiko Mihara Satoshi Watanabe Nasir K. Bashiruddin Nozomi Nakamura Kyoko Matoba Yumi Sano Rumit Maini Yizhen Yin Katsuya Sakai Takao Arimori Kunio Matsumoto Hiroaki Suga Junichi Takagi
author_sort	Emiko Mihara
title	Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins
title_short	Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins
title_full	Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins
title_fullStr	Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins
title_full_unstemmed	Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins
title_sort	lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b6402a431ea3401381e2112d57500bf8
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Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins

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