The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan

The transcription factor Gcn4 is known to regulate yeast amino acid synthesis. Here, the authors show that Gcn4 also acts as a repressor of protein biosynthesis in a range of conditions that enhance yeast lifespan, such as ribosomal protein knockout, calorie restriction or mTOR inhibition.

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Autores principales: Nitish Mittal, Joao C. Guimaraes, Thomas Gross, Alexander Schmidt, Arnau Vina-Vilaseca, Danny D. Nedialkova, Florian Aeschimann, Sebastian A. Leidel, Anne Spang, Mihaela Zavolan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b6439a80872547a384d1bede0c79d78b
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