The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan

The transcription factor Gcn4 is known to regulate yeast amino acid synthesis. Here, the authors show that Gcn4 also acts as a repressor of protein biosynthesis in a range of conditions that enhance yeast lifespan, such as ribosomal protein knockout, calorie restriction or mTOR inhibition.

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Autores principales:	Nitish Mittal, Joao C. Guimaraes, Thomas Gross, Alexander Schmidt, Arnau Vina-Vilaseca, Danny D. Nedialkova, Florian Aeschimann, Sebastian A. Leidel, Anne Spang, Mihaela Zavolan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6439a80872547a384d1bede0c79d78b
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spelling	oai:doaj.org-article:b6439a80872547a384d1bede0c79d78b2021-12-02T14:42:11ZThe Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan10.1038/s41467-017-00539-y2041-1723https://doaj.org/article/b6439a80872547a384d1bede0c79d78b2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00539-yhttps://doaj.org/toc/2041-1723The transcription factor Gcn4 is known to regulate yeast amino acid synthesis. Here, the authors show that Gcn4 also acts as a repressor of protein biosynthesis in a range of conditions that enhance yeast lifespan, such as ribosomal protein knockout, calorie restriction or mTOR inhibition.Nitish MittalJoao C. GuimaraesThomas GrossAlexander SchmidtArnau Vina-VilasecaDanny D. NedialkovaFlorian AeschimannSebastian A. LeidelAnne SpangMihaela ZavolanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nitish Mittal Joao C. Guimaraes Thomas Gross Alexander Schmidt Arnau Vina-Vilaseca Danny D. Nedialkova Florian Aeschimann Sebastian A. Leidel Anne Spang Mihaela Zavolan The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan
description	The transcription factor Gcn4 is known to regulate yeast amino acid synthesis. Here, the authors show that Gcn4 also acts as a repressor of protein biosynthesis in a range of conditions that enhance yeast lifespan, such as ribosomal protein knockout, calorie restriction or mTOR inhibition.
format	article
author	Nitish Mittal Joao C. Guimaraes Thomas Gross Alexander Schmidt Arnau Vina-Vilaseca Danny D. Nedialkova Florian Aeschimann Sebastian A. Leidel Anne Spang Mihaela Zavolan
author_facet	Nitish Mittal Joao C. Guimaraes Thomas Gross Alexander Schmidt Arnau Vina-Vilaseca Danny D. Nedialkova Florian Aeschimann Sebastian A. Leidel Anne Spang Mihaela Zavolan
author_sort	Nitish Mittal
title	The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan
title_short	The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan
title_full	The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan
title_fullStr	The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan
title_full_unstemmed	The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan
title_sort	gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b6439a80872547a384d1bede0c79d78b
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The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan

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