Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses

Sun et al. show that hepatitis C virus or free-fatty acids increase lipid droplets and apolipoprotein J (ApoJ) expression while ApoJ silencing alleviates hepatic lipid accumulation. This study suggests that hepatic ApoJ may activate sterol O-acyltransferase 2 to supply cholesteryl-ester for lipid lo...

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Autores principales: Hung-Yu Sun, Tzu-Ying Chen, Yu-Ching Tan, Chun-Hsiang Wang, Kung-Chia Young
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b6481110f1c447b693020f4fbbc72f40
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Sumario:Sun et al. show that hepatitis C virus or free-fatty acids increase lipid droplets and apolipoprotein J (ApoJ) expression while ApoJ silencing alleviates hepatic lipid accumulation. This study suggests that hepatic ApoJ may activate sterol O-acyltransferase 2 to supply cholesteryl-ester for lipid loads, thus presenting ApoJ as a promising target for treating stress-induced steatosis.