Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses

Sun et al. show that hepatitis C virus or free-fatty acids increase lipid droplets and apolipoprotein J (ApoJ) expression while ApoJ silencing alleviates hepatic lipid accumulation. This study suggests that hepatic ApoJ may activate sterol O-acyltransferase 2 to supply cholesteryl-ester for lipid lo...

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Autores principales:	Hung-Yu Sun, Tzu-Ying Chen, Yu-Ching Tan, Chun-Hsiang Wang, Kung-Chia Young
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b6481110f1c447b693020f4fbbc72f40
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spelling	oai:doaj.org-article:b6481110f1c447b693020f4fbbc72f402021-12-02T15:43:17ZSterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses10.1038/s42003-021-02093-22399-3642https://doaj.org/article/b6481110f1c447b693020f4fbbc72f402021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02093-2https://doaj.org/toc/2399-3642Sun et al. show that hepatitis C virus or free-fatty acids increase lipid droplets and apolipoprotein J (ApoJ) expression while ApoJ silencing alleviates hepatic lipid accumulation. This study suggests that hepatic ApoJ may activate sterol O-acyltransferase 2 to supply cholesteryl-ester for lipid loads, thus presenting ApoJ as a promising target for treating stress-induced steatosis.Hung-Yu SunTzu-Ying ChenYu-Ching TanChun-Hsiang WangKung-Chia YoungNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Hung-Yu Sun Tzu-Ying Chen Yu-Ching Tan Chun-Hsiang Wang Kung-Chia Young Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses
description	Sun et al. show that hepatitis C virus or free-fatty acids increase lipid droplets and apolipoprotein J (ApoJ) expression while ApoJ silencing alleviates hepatic lipid accumulation. This study suggests that hepatic ApoJ may activate sterol O-acyltransferase 2 to supply cholesteryl-ester for lipid loads, thus presenting ApoJ as a promising target for treating stress-induced steatosis.
format	article
author	Hung-Yu Sun Tzu-Ying Chen Yu-Ching Tan Chun-Hsiang Wang Kung-Chia Young
author_facet	Hung-Yu Sun Tzu-Ying Chen Yu-Ching Tan Chun-Hsiang Wang Kung-Chia Young
author_sort	Hung-Yu Sun
title	Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses
title_short	Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses
title_full	Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses
title_fullStr	Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses
title_full_unstemmed	Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses
title_sort	sterol o-acyltransferase 2 chaperoned by apolipoprotein j facilitates hepatic lipid accumulation following viral and nutrient stresses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b6481110f1c447b693020f4fbbc72f40
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Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses

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