General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins

Synthesis of peptides and proteins containing multiple disulfide bonds is challenging, limiting the elucidation of their biological functions. Here, the authors report a general synthetic strategy for fast formation of two and three disulfide bonds in peptides and proteins, and apply it to prepare s...

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Autores principales: Shay Laps, Fatima Atamleh, Guy Kamnesky, Hao Sun, Ashraf Brik
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b650fa8fa31e44d7bc9a77cbbc106aff
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