General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins

Synthesis of peptides and proteins containing multiple disulfide bonds is challenging, limiting the elucidation of their biological functions. Here, the authors report a general synthetic strategy for fast formation of two and three disulfide bonds in peptides and proteins, and apply it to prepare s...

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Autores principales:	Shay Laps, Fatima Atamleh, Guy Kamnesky, Hao Sun, Ashraf Brik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b650fa8fa31e44d7bc9a77cbbc106aff
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spelling	oai:doaj.org-article:b650fa8fa31e44d7bc9a77cbbc106aff2021-12-02T14:11:09ZGeneral synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins10.1038/s41467-021-21209-02041-1723https://doaj.org/article/b650fa8fa31e44d7bc9a77cbbc106aff2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21209-0https://doaj.org/toc/2041-1723Synthesis of peptides and proteins containing multiple disulfide bonds is challenging, limiting the elucidation of their biological functions. Here, the authors report a general synthetic strategy for fast formation of two and three disulfide bonds in peptides and proteins, and apply it to prepare several therapeutically important peptides.Shay LapsFatima AtamlehGuy KamneskyHao SunAshraf BrikNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shay Laps Fatima Atamleh Guy Kamnesky Hao Sun Ashraf Brik General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins
description	Synthesis of peptides and proteins containing multiple disulfide bonds is challenging, limiting the elucidation of their biological functions. Here, the authors report a general synthetic strategy for fast formation of two and three disulfide bonds in peptides and proteins, and apply it to prepare several therapeutically important peptides.
format	article
author	Shay Laps Fatima Atamleh Guy Kamnesky Hao Sun Ashraf Brik
author_facet	Shay Laps Fatima Atamleh Guy Kamnesky Hao Sun Ashraf Brik
author_sort	Shay Laps
title	General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins
title_short	General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins
title_full	General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins
title_fullStr	General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins
title_full_unstemmed	General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins
title_sort	general synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b650fa8fa31e44d7bc9a77cbbc106aff
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General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins

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