Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development

De novo DNA methylation is carried out by DNMT3A and DNMT3B, but the distinct functions of these two enzymes is poorly understood. Here the authors present a comprehensive, genome-wide identification of target sites for de novo DNA methylation by the DNMT3A and DNMT3B in mouse ES cells and embryos,...

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Main Authors:	Masaki Yagi, Mio Kabata, Akito Tanaka, Tomoyo Ukai, Sho Ohta, Kazuhiko Nakabayashi, Masahito Shimizu, Kenichiro Hata, Alexander Meissner, Takuya Yamamoto, Yasuhiro Yamada
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/b65b6e33e3a14ce7b532093c4f2b9276
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spelling	oai:doaj.org-article:b65b6e33e3a14ce7b532093c4f2b92762021-12-02T17:14:22ZIdentification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development10.1038/s41467-020-16989-w2041-1723https://doaj.org/article/b65b6e33e3a14ce7b532093c4f2b92762020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16989-whttps://doaj.org/toc/2041-1723De novo DNA methylation is carried out by DNMT3A and DNMT3B, but the distinct functions of these two enzymes is poorly understood. Here the authors present a comprehensive, genome-wide identification of target sites for de novo DNA methylation by the DNMT3A and DNMT3B in mouse ES cells and embryos, identifying unique de novo DNA methylation target sites for both DNMT3 enzymes.Masaki YagiMio KabataAkito TanakaTomoyo UkaiSho OhtaKazuhiko NakabayashiMasahito ShimizuKenichiro HataAlexander MeissnerTakuya YamamotoYasuhiro YamadaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Masaki Yagi Mio Kabata Akito Tanaka Tomoyo Ukai Sho Ohta Kazuhiko Nakabayashi Masahito Shimizu Kenichiro Hata Alexander Meissner Takuya Yamamoto Yasuhiro Yamada Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development
description	De novo DNA methylation is carried out by DNMT3A and DNMT3B, but the distinct functions of these two enzymes is poorly understood. Here the authors present a comprehensive, genome-wide identification of target sites for de novo DNA methylation by the DNMT3A and DNMT3B in mouse ES cells and embryos, identifying unique de novo DNA methylation target sites for both DNMT3 enzymes.
format	article
author	Masaki Yagi Mio Kabata Akito Tanaka Tomoyo Ukai Sho Ohta Kazuhiko Nakabayashi Masahito Shimizu Kenichiro Hata Alexander Meissner Takuya Yamamoto Yasuhiro Yamada
author_facet	Masaki Yagi Mio Kabata Akito Tanaka Tomoyo Ukai Sho Ohta Kazuhiko Nakabayashi Masahito Shimizu Kenichiro Hata Alexander Meissner Takuya Yamamoto Yasuhiro Yamada
author_sort	Masaki Yagi
title	Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development
title_short	Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development
title_full	Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development
title_fullStr	Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development
title_full_unstemmed	Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development
title_sort	identification of distinct loci for de novo dna methylation by dnmt3a and dnmt3b during mammalian development
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b65b6e33e3a14ce7b532093c4f2b9276
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Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development

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