Reverse C-glycosidase reaction provides C-nucleotide building blocks of xenobiotic nucleic acids

C-nucleosides are analogues of the canonical N-nucleosides and, despite their synthetic value, biocatalysis has not targeted them yet. Here, the authors report a pseudouridine monophosphate C-glycosidase enzyme for selective 5-β-C-glycosylation of uracil and its derivatives from pentose 5- phosphate...

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Autores principales: Martin Pfeiffer, Bernd Nidetzky
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b67940dc96204bd1a7efa6244b05d5f4
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