Reverse C-glycosidase reaction provides C-nucleotide building blocks of xenobiotic nucleic acids

C-nucleosides are analogues of the canonical N-nucleosides and, despite their synthetic value, biocatalysis has not targeted them yet. Here, the authors report a pseudouridine monophosphate C-glycosidase enzyme for selective 5-β-C-glycosylation of uracil and its derivatives from pentose 5- phosphate...

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Autores principales:	Martin Pfeiffer, Bernd Nidetzky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b67940dc96204bd1a7efa6244b05d5f4
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spelling	oai:doaj.org-article:b67940dc96204bd1a7efa6244b05d5f42021-12-02T10:48:19ZReverse C-glycosidase reaction provides C-nucleotide building blocks of xenobiotic nucleic acids10.1038/s41467-020-20035-02041-1723https://doaj.org/article/b67940dc96204bd1a7efa6244b05d5f42020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20035-0https://doaj.org/toc/2041-1723C-nucleosides are analogues of the canonical N-nucleosides and, despite their synthetic value, biocatalysis has not targeted them yet. Here, the authors report a pseudouridine monophosphate C-glycosidase enzyme for selective 5-β-C-glycosylation of uracil and its derivatives from pentose 5- phosphate substrates.Martin PfeifferBernd NidetzkyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Pfeiffer Bernd Nidetzky Reverse C-glycosidase reaction provides C-nucleotide building blocks of xenobiotic nucleic acids
description	C-nucleosides are analogues of the canonical N-nucleosides and, despite their synthetic value, biocatalysis has not targeted them yet. Here, the authors report a pseudouridine monophosphate C-glycosidase enzyme for selective 5-β-C-glycosylation of uracil and its derivatives from pentose 5- phosphate substrates.
format	article
author	Martin Pfeiffer Bernd Nidetzky
author_facet	Martin Pfeiffer Bernd Nidetzky
author_sort	Martin Pfeiffer
title	Reverse C-glycosidase reaction provides C-nucleotide building blocks of xenobiotic nucleic acids
title_short	Reverse C-glycosidase reaction provides C-nucleotide building blocks of xenobiotic nucleic acids
title_full	Reverse C-glycosidase reaction provides C-nucleotide building blocks of xenobiotic nucleic acids
title_fullStr	Reverse C-glycosidase reaction provides C-nucleotide building blocks of xenobiotic nucleic acids
title_full_unstemmed	Reverse C-glycosidase reaction provides C-nucleotide building blocks of xenobiotic nucleic acids
title_sort	reverse c-glycosidase reaction provides c-nucleotide building blocks of xenobiotic nucleic acids
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b67940dc96204bd1a7efa6244b05d5f4
work_keys_str_mv	AT martinpfeiffer reversecglycosidasereactionprovidescnucleotidebuildingblocksofxenobioticnucleicacids AT berndnidetzky reversecglycosidasereactionprovidescnucleotidebuildingblocksofxenobioticnucleicacids
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Reverse C-glycosidase reaction provides C-nucleotide building blocks of xenobiotic nucleic acids

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