An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer

KRAS-driven cancers remain refractory to current clinical therapies. In this study, the authors show that lung and pancreatic cancers expressing oncogenic KRAS can be targeted by genetic inhibition of FOSL1, which involves downregulation of genes of the mitotic machinery.

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Autores principales:	Adrian Vallejo, Naiara Perurena, Elisabet Guruceaga, Pawel K. Mazur, Susana Martinez-Canarias, Carolina Zandueta, Karmele Valencia, Andrea Arricibita, Dana Gwinn, Leanne C. Sayles, Chen-Hua Chuang, Laura Guembe, Peter Bailey, David K. Chang, Andrew Biankin, Mariano Ponz-Sarvise, Jesper B. Andersen, Purvesh Khatri, Aline Bozec, E. Alejandro Sweet-Cordero, Julien Sage, Fernando Lecanda, Silve Vicent
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b67e9794d6104499b87c9422aa01ff4a
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spelling	oai:doaj.org-article:b67e9794d6104499b87c9422aa01ff4a2021-12-02T14:42:36ZAn integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer10.1038/ncomms142942041-1723https://doaj.org/article/b67e9794d6104499b87c9422aa01ff4a2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14294https://doaj.org/toc/2041-1723KRAS-driven cancers remain refractory to current clinical therapies. In this study, the authors show that lung and pancreatic cancers expressing oncogenic KRAS can be targeted by genetic inhibition of FOSL1, which involves downregulation of genes of the mitotic machinery.Adrian VallejoNaiara PerurenaElisabet GuruceagaPawel K. MazurSusana Martinez-CanariasCarolina ZanduetaKarmele ValenciaAndrea ArricibitaDana GwinnLeanne C. SaylesChen-Hua ChuangLaura GuembePeter BaileyDavid K. ChangAndrew BiankinMariano Ponz-SarviseJesper B. AndersenPurvesh KhatriAline BozecE. Alejandro Sweet-CorderoJulien SageFernando LecandaSilve VicentNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adrian Vallejo Naiara Perurena Elisabet Guruceaga Pawel K. Mazur Susana Martinez-Canarias Carolina Zandueta Karmele Valencia Andrea Arricibita Dana Gwinn Leanne C. Sayles Chen-Hua Chuang Laura Guembe Peter Bailey David K. Chang Andrew Biankin Mariano Ponz-Sarvise Jesper B. Andersen Purvesh Khatri Aline Bozec E. Alejandro Sweet-Cordero Julien Sage Fernando Lecanda Silve Vicent An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer
description	KRAS-driven cancers remain refractory to current clinical therapies. In this study, the authors show that lung and pancreatic cancers expressing oncogenic KRAS can be targeted by genetic inhibition of FOSL1, which involves downregulation of genes of the mitotic machinery.
format	article
author	Adrian Vallejo Naiara Perurena Elisabet Guruceaga Pawel K. Mazur Susana Martinez-Canarias Carolina Zandueta Karmele Valencia Andrea Arricibita Dana Gwinn Leanne C. Sayles Chen-Hua Chuang Laura Guembe Peter Bailey David K. Chang Andrew Biankin Mariano Ponz-Sarvise Jesper B. Andersen Purvesh Khatri Aline Bozec E. Alejandro Sweet-Cordero Julien Sage Fernando Lecanda Silve Vicent
author_facet	Adrian Vallejo Naiara Perurena Elisabet Guruceaga Pawel K. Mazur Susana Martinez-Canarias Carolina Zandueta Karmele Valencia Andrea Arricibita Dana Gwinn Leanne C. Sayles Chen-Hua Chuang Laura Guembe Peter Bailey David K. Chang Andrew Biankin Mariano Ponz-Sarvise Jesper B. Andersen Purvesh Khatri Aline Bozec E. Alejandro Sweet-Cordero Julien Sage Fernando Lecanda Silve Vicent
author_sort	Adrian Vallejo
title	An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer
title_short	An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer
title_full	An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer
title_fullStr	An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer
title_full_unstemmed	An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer
title_sort	integrative approach unveils fosl1 as an oncogene vulnerability in kras-driven lung and pancreatic cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b67e9794d6104499b87c9422aa01ff4a
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An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer

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