An unexpected protein interaction promotes drug resistance in leukemia

An unexpected protein interaction promotes drug resistance in leukemia

ABCC4 is a chemotherapeutic drug exporter highly expressed in acute myeloid leukemia. Here, the authors demonstrate that MPP1 anchors ABCC4 to the outer cell membrane mediating drug resistance in leukemic cells and identify antimycin A as a chemical probe that disrupts such interaction and restores...

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Autores principales: Aaron Pitre, Yubin Ge, Wenwei Lin, Yao Wang, Yu Fukuda, Jamshid Temirov, Aaron H. Phillips, Jennifer L. Peters, Yiping Fan, Jing Ma, Amanda Nourse, Chandrima Sinha, Hai Lin, Richard Kriwacki, James R. Downing, Tanja A. Gruber, Victoria E. Centonze, Anjaparavanda P. Naren, Taosheng Chen, John D. Schuetz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b6c8588bcf0a40118828477b2bfbf11e
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spelling oai:doaj.org-article:b6c8588bcf0a40118828477b2bfbf11e2021-12-02T14:40:24ZAn unexpected protein interaction promotes drug resistance in leukemia10.1038/s41467-017-01678-y2041-1723https://doaj.org/article/b6c8588bcf0a40118828477b2bfbf11e2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01678-yhttps://doaj.org/toc/2041-1723ABCC4 is a chemotherapeutic drug exporter highly expressed in acute myeloid leukemia. Here, the authors demonstrate that MPP1 anchors ABCC4 to the outer cell membrane mediating drug resistance in leukemic cells and identify antimycin A as a chemical probe that disrupts such interaction and restores sensitivity.Aaron PitreYubin GeWenwei LinYao WangYu FukudaJamshid TemirovAaron H. PhillipsJennifer L. PetersYiping FanJing MaAmanda NourseChandrima SinhaHai LinRichard KriwackiJames R. DowningTanja A. GruberVictoria E. CentonzeAnjaparavanda P. NarenTaosheng ChenJohn D. SchuetzNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Aaron Pitre
Yubin Ge
Wenwei Lin
Yao Wang
Yu Fukuda
Jamshid Temirov
Aaron H. Phillips
Jennifer L. Peters
Yiping Fan
Jing Ma
Amanda Nourse
Chandrima Sinha
Hai Lin
Richard Kriwacki
James R. Downing
Tanja A. Gruber
Victoria E. Centonze
Anjaparavanda P. Naren
Taosheng Chen
John D. Schuetz
An unexpected protein interaction promotes drug resistance in leukemia
description ABCC4 is a chemotherapeutic drug exporter highly expressed in acute myeloid leukemia. Here, the authors demonstrate that MPP1 anchors ABCC4 to the outer cell membrane mediating drug resistance in leukemic cells and identify antimycin A as a chemical probe that disrupts such interaction and restores sensitivity.
format article
author Aaron Pitre
Yubin Ge
Wenwei Lin
Yao Wang
Yu Fukuda
Jamshid Temirov
Aaron H. Phillips
Jennifer L. Peters
Yiping Fan
Jing Ma
Amanda Nourse
Chandrima Sinha
Hai Lin
Richard Kriwacki
James R. Downing
Tanja A. Gruber
Victoria E. Centonze
Anjaparavanda P. Naren
Taosheng Chen
John D. Schuetz
author_facet Aaron Pitre
Yubin Ge
Wenwei Lin
Yao Wang
Yu Fukuda
Jamshid Temirov
Aaron H. Phillips
Jennifer L. Peters
Yiping Fan
Jing Ma
Amanda Nourse
Chandrima Sinha
Hai Lin
Richard Kriwacki
James R. Downing
Tanja A. Gruber
Victoria E. Centonze
Anjaparavanda P. Naren
Taosheng Chen
John D. Schuetz
author_sort Aaron Pitre
title An unexpected protein interaction promotes drug resistance in leukemia
title_short An unexpected protein interaction promotes drug resistance in leukemia
title_full An unexpected protein interaction promotes drug resistance in leukemia
title_fullStr An unexpected protein interaction promotes drug resistance in leukemia
title_full_unstemmed An unexpected protein interaction promotes drug resistance in leukemia
title_sort unexpected protein interaction promotes drug resistance in leukemia
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/b6c8588bcf0a40118828477b2bfbf11e
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