Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

Invariant natural killer T (iNKT) cells rapidly enhance cytokine secretion and effector function following activation, but the underlying mechanism is still unclear. Here the authors show that an endoplasmic reticulum stress sensor, inositol-requiring enzyme 1α, activates the p38 kinase to stabilize...

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Autores principales: Srinath Govindarajan, Djoere Gaublomme, Renée Van der Cruyssen, Eveline Verheugen, Sofie Van Gassen, Yvan Saeys, Simon Tavernier, Takao Iwawaki, Yehudi Bloch, Savvas. N. Savvides, Bart N. Lambrecht, Sophie Janssens, Dirk Elewaut, Michael B. Drennan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/b6d32051b63e4b37881f01ffdff4d01b
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spelling oai:doaj.org-article:b6d32051b63e4b37881f01ffdff4d01b2021-12-02T15:34:44ZStabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha10.1038/s41467-018-07758-x2041-1723https://doaj.org/article/b6d32051b63e4b37881f01ffdff4d01b2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07758-xhttps://doaj.org/toc/2041-1723Invariant natural killer T (iNKT) cells rapidly enhance cytokine secretion and effector function following activation, but the underlying mechanism is still unclear. Here the authors show that an endoplasmic reticulum stress sensor, inositol-requiring enzyme 1α, activates the p38 kinase to stabilize cytokine mRNA for enhanced iNKT functions.Srinath GovindarajanDjoere GaublommeRenée Van der CruyssenEveline VerheugenSofie Van GassenYvan SaeysSimon TavernierTakao IwawakiYehudi BlochSavvas. N. SavvidesBart N. LambrechtSophie JanssensDirk ElewautMichael B. DrennanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Srinath Govindarajan
Djoere Gaublomme
Renée Van der Cruyssen
Eveline Verheugen
Sofie Van Gassen
Yvan Saeys
Simon Tavernier
Takao Iwawaki
Yehudi Bloch
Savvas. N. Savvides
Bart N. Lambrecht
Sophie Janssens
Dirk Elewaut
Michael B. Drennan
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha
description Invariant natural killer T (iNKT) cells rapidly enhance cytokine secretion and effector function following activation, but the underlying mechanism is still unclear. Here the authors show that an endoplasmic reticulum stress sensor, inositol-requiring enzyme 1α, activates the p38 kinase to stabilize cytokine mRNA for enhanced iNKT functions.
format article
author Srinath Govindarajan
Djoere Gaublomme
Renée Van der Cruyssen
Eveline Verheugen
Sofie Van Gassen
Yvan Saeys
Simon Tavernier
Takao Iwawaki
Yehudi Bloch
Savvas. N. Savvides
Bart N. Lambrecht
Sophie Janssens
Dirk Elewaut
Michael B. Drennan
author_facet Srinath Govindarajan
Djoere Gaublomme
Renée Van der Cruyssen
Eveline Verheugen
Sofie Van Gassen
Yvan Saeys
Simon Tavernier
Takao Iwawaki
Yehudi Bloch
Savvas. N. Savvides
Bart N. Lambrecht
Sophie Janssens
Dirk Elewaut
Michael B. Drennan
author_sort Srinath Govindarajan
title Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha
title_short Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha
title_full Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha
title_fullStr Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha
title_full_unstemmed Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha
title_sort stabilization of cytokine mrnas in inkt cells requires the serine-threonine kinase ire1alpha
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/b6d32051b63e4b37881f01ffdff4d01b
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