STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

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STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

PD-L1 accumulates on cancer stem cells and favours immune evasion but the mechanism underlying this accumulation are unknown. Here the authors show that epithelial-mesenchymal transition induces glycosylation and stabilisation of PD-L1; antagonising this process renders cancer cells sensitive to ant...

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Auteurs principaux:	Jung-Mao Hsu, Weiya Xia, Yi-Hsin Hsu, Li-Chuan Chan, Wen-Hsuan Yu, Jong-Ho Cha, Chun-Te Chen, Hsin-Wei Liao, Chu-Wei Kuo, Kay-Hooi Khoo, Jennifer L. Hsu, Chia-Wei Li, Seung-Oe Lim, Shih-Shin Chang, Yi-Chun Chen, Guo-xin Ren, Mien-Chie Hung
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/b6e5e0697fa048aeb6392035c75e7d85
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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