Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
IL-15 signals through STAT5 to modulate natural killer (NK) cell maturation, function and homeostasis, but the specific contributions of STAT5 dimers and tetramers are still unclear. Here the authors show that, while STAT5 dimers are sufficient for NK development, STAT5 tetramers are essential for N...
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Nature Portfolio
2017
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oai:doaj.org-article:b737b1cb8b61414c848b3ccab3e8881b2021-12-02T14:40:36ZCritical functions for STAT5 tetramers in the maturation and survival of natural killer cells10.1038/s41467-017-01477-52041-1723https://doaj.org/article/b737b1cb8b61414c848b3ccab3e8881b2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01477-5https://doaj.org/toc/2041-1723IL-15 signals through STAT5 to modulate natural killer (NK) cell maturation, function and homeostasis, but the specific contributions of STAT5 dimers and tetramers are still unclear. Here the authors show that, while STAT5 dimers are sufficient for NK development, STAT5 tetramers are essential for NK homoeostasis by modulating apoptosis.Jian-Xin LinNing DuPeng LiMajid KazemianTesfay GebregiorgisRosanne SpolskiWarren J. LeonardNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
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Science Q Jian-Xin Lin Ning Du Peng Li Majid Kazemian Tesfay Gebregiorgis Rosanne Spolski Warren J. Leonard Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells |
description |
IL-15 signals through STAT5 to modulate natural killer (NK) cell maturation, function and homeostasis, but the specific contributions of STAT5 dimers and tetramers are still unclear. Here the authors show that, while STAT5 dimers are sufficient for NK development, STAT5 tetramers are essential for NK homoeostasis by modulating apoptosis. |
format |
article |
author |
Jian-Xin Lin Ning Du Peng Li Majid Kazemian Tesfay Gebregiorgis Rosanne Spolski Warren J. Leonard |
author_facet |
Jian-Xin Lin Ning Du Peng Li Majid Kazemian Tesfay Gebregiorgis Rosanne Spolski Warren J. Leonard |
author_sort |
Jian-Xin Lin |
title |
Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells |
title_short |
Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells |
title_full |
Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells |
title_fullStr |
Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells |
title_full_unstemmed |
Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells |
title_sort |
critical functions for stat5 tetramers in the maturation and survival of natural killer cells |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/b737b1cb8b61414c848b3ccab3e8881b |
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