Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells

IL-15 signals through STAT5 to modulate natural killer (NK) cell maturation, function and homeostasis, but the specific contributions of STAT5 dimers and tetramers are still unclear. Here the authors show that, while STAT5 dimers are sufficient for NK development, STAT5 tetramers are essential for N...

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Autores principales: Jian-Xin Lin, Ning Du, Peng Li, Majid Kazemian, Tesfay Gebregiorgis, Rosanne Spolski, Warren J. Leonard
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b737b1cb8b61414c848b3ccab3e8881b
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spelling oai:doaj.org-article:b737b1cb8b61414c848b3ccab3e8881b2021-12-02T14:40:36ZCritical functions for STAT5 tetramers in the maturation and survival of natural killer cells10.1038/s41467-017-01477-52041-1723https://doaj.org/article/b737b1cb8b61414c848b3ccab3e8881b2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01477-5https://doaj.org/toc/2041-1723IL-15 signals through STAT5 to modulate natural killer (NK) cell maturation, function and homeostasis, but the specific contributions of STAT5 dimers and tetramers are still unclear. Here the authors show that, while STAT5 dimers are sufficient for NK development, STAT5 tetramers are essential for NK homoeostasis by modulating apoptosis.Jian-Xin LinNing DuPeng LiMajid KazemianTesfay GebregiorgisRosanne SpolskiWarren J. LeonardNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jian-Xin Lin
Ning Du
Peng Li
Majid Kazemian
Tesfay Gebregiorgis
Rosanne Spolski
Warren J. Leonard
Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
description IL-15 signals through STAT5 to modulate natural killer (NK) cell maturation, function and homeostasis, but the specific contributions of STAT5 dimers and tetramers are still unclear. Here the authors show that, while STAT5 dimers are sufficient for NK development, STAT5 tetramers are essential for NK homoeostasis by modulating apoptosis.
format article
author Jian-Xin Lin
Ning Du
Peng Li
Majid Kazemian
Tesfay Gebregiorgis
Rosanne Spolski
Warren J. Leonard
author_facet Jian-Xin Lin
Ning Du
Peng Li
Majid Kazemian
Tesfay Gebregiorgis
Rosanne Spolski
Warren J. Leonard
author_sort Jian-Xin Lin
title Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
title_short Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
title_full Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
title_fullStr Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
title_full_unstemmed Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
title_sort critical functions for stat5 tetramers in the maturation and survival of natural killer cells
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/b737b1cb8b61414c848b3ccab3e8881b
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