Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells

IL-15 signals through STAT5 to modulate natural killer (NK) cell maturation, function and homeostasis, but the specific contributions of STAT5 dimers and tetramers are still unclear. Here the authors show that, while STAT5 dimers are sufficient for NK development, STAT5 tetramers are essential for N...

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Main Authors:	Jian-Xin Lin, Ning Du, Peng Li, Majid Kazemian, Tesfay Gebregiorgis, Rosanne Spolski, Warren J. Leonard
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/b737b1cb8b61414c848b3ccab3e8881b
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spelling	oai:doaj.org-article:b737b1cb8b61414c848b3ccab3e8881b2021-12-02T14:40:36ZCritical functions for STAT5 tetramers in the maturation and survival of natural killer cells10.1038/s41467-017-01477-52041-1723https://doaj.org/article/b737b1cb8b61414c848b3ccab3e8881b2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01477-5https://doaj.org/toc/2041-1723IL-15 signals through STAT5 to modulate natural killer (NK) cell maturation, function and homeostasis, but the specific contributions of STAT5 dimers and tetramers are still unclear. Here the authors show that, while STAT5 dimers are sufficient for NK development, STAT5 tetramers are essential for NK homoeostasis by modulating apoptosis.Jian-Xin LinNing DuPeng LiMajid KazemianTesfay GebregiorgisRosanne SpolskiWarren J. LeonardNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jian-Xin Lin Ning Du Peng Li Majid Kazemian Tesfay Gebregiorgis Rosanne Spolski Warren J. Leonard Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
description	IL-15 signals through STAT5 to modulate natural killer (NK) cell maturation, function and homeostasis, but the specific contributions of STAT5 dimers and tetramers are still unclear. Here the authors show that, while STAT5 dimers are sufficient for NK development, STAT5 tetramers are essential for NK homoeostasis by modulating apoptosis.
format	article
author	Jian-Xin Lin Ning Du Peng Li Majid Kazemian Tesfay Gebregiorgis Rosanne Spolski Warren J. Leonard
author_facet	Jian-Xin Lin Ning Du Peng Li Majid Kazemian Tesfay Gebregiorgis Rosanne Spolski Warren J. Leonard
author_sort	Jian-Xin Lin
title	Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
title_short	Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
title_full	Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
title_fullStr	Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
title_full_unstemmed	Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
title_sort	critical functions for stat5 tetramers in the maturation and survival of natural killer cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b737b1cb8b61414c848b3ccab3e8881b
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Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells

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