aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis

Squamous epithelia present actin-rich microridges on the apical surface, but the mechanism of their formation is not known. Here the authors show that, in zebrafish epidermis, the exclusion of the basolateral regulator Lgl from the apical domain by atypical protein kinase C prevents precocious elong...

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Autores principales:	Renuka Raman, Indraneel Damle, Rahul Rote, Shamik Banerjee, Chaitanya Dingare, Mahendra Sonawane
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b7590a5713f845c58451d66693f083c7
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spelling	oai:doaj.org-article:b7590a5713f845c58451d66693f083c72021-12-02T17:32:20ZaPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis10.1038/ncomms116432041-1723https://doaj.org/article/b7590a5713f845c58451d66693f083c72016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11643https://doaj.org/toc/2041-1723Squamous epithelia present actin-rich microridges on the apical surface, but the mechanism of their formation is not known. Here the authors show that, in zebrafish epidermis, the exclusion of the basolateral regulator Lgl from the apical domain by atypical protein kinase C prevents precocious elongation and fusion of microridges.Renuka RamanIndraneel DamleRahul RoteShamik BanerjeeChaitanya DingareMahendra SonawaneNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Renuka Raman Indraneel Damle Rahul Rote Shamik Banerjee Chaitanya Dingare Mahendra Sonawane aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis
description	Squamous epithelia present actin-rich microridges on the apical surface, but the mechanism of their formation is not known. Here the authors show that, in zebrafish epidermis, the exclusion of the basolateral regulator Lgl from the apical domain by atypical protein kinase C prevents precocious elongation and fusion of microridges.
format	article
author	Renuka Raman Indraneel Damle Rahul Rote Shamik Banerjee Chaitanya Dingare Mahendra Sonawane
author_facet	Renuka Raman Indraneel Damle Rahul Rote Shamik Banerjee Chaitanya Dingare Mahendra Sonawane
author_sort	Renuka Raman
title	aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis
title_short	aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis
title_full	aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis
title_fullStr	aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis
title_full_unstemmed	aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis
title_sort	apkc regulates apical localization of lgl to restrict elongation of microridges in developing zebrafish epidermis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b7590a5713f845c58451d66693f083c7
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aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis

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