Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma
Despite the high sensitivity of SERS analysis, non-specific binding of proteins can impact the effectiveness in biologically important media such as blood. Here the authors report a SERS substrate modified to prevent protein fouling and demonstrate drug detection in undiluted plasma.
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Main Authors: | Fang Sun, Hsiang-Chieh Hung, Andrew Sinclair, Peng Zhang, Tao Bai, Daniel David Galvan, Priyesh Jain, Bowen Li, Shaoyi Jiang, Qiuming Yu |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2016
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Subjects: | |
Online Access: | https://doaj.org/article/b78697f9b95a451c8e56f154160ba36f |
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