Deep learning model enables the discovery of a novel immunotherapeutic agent regulating the kynurenine pathway

Deep learning model enables the discovery of a novel immunotherapeutic agent regulating the kynurenine pathway

Kynurenine (Kyn) is a key inducer of an immunosuppressive tumor microenvironment (TME). Although indoleamine 2,3-dioxygenase (IDO)-selective inhibitors have been developed to suppress the Kyn pathway, the results were not satisfactory due to the presence of various opposing mechanisms. Here, we empl...

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Bibliographic Details
Main Authors: Jeong Hun Kim, Won Suk Lee, Hye Jin Lee, Hannah Yang, Seung Joon Lee, so Jung Kong, Soyeon Je, Hyun-Jin Yang, Jongsun Jung, Jaekyung Cheon, Beodeul Kang, Hong Jae Chon, Chan Kim
Format: article
Language:EN
Published: Taylor & Francis Group 2021
Subjects:
kynurenine pathway
tumor microenvironment
indoleamine 2
3-dioxygenase
deep learning technology
Immunologic diseases. Allergy
RC581-607
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/b79d3c54e4ff44589373a0cee089c2d6
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https://doaj.org/article/b79d3c54e4ff44589373a0cee089c2d6

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