Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State
Elucidating the structure and function of the HIV-1 outer envelope proteins is critical for the design of an effective vaccine. Despite the availability of many high-resolution structures, key functional correlates in the envelope trimer remain undefined.
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American Society for Microbiology
2021
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oai:doaj.org-article:b7ce808852144799b0fcfef045f0734b2021-11-03T18:56:10ZFunctional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State2150-751110.1128/mBio.00090-21https://doaj.org/article/b7ce808852144799b0fcfef045f0734b2021-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00090-21https://doaj.org/toc/2150-7511 Elucidating the structure and function of the HIV-1 outer envelope proteins is critical for the design of an effective vaccine. Despite the availability of many high-resolution structures, key functional correlates in the envelope trimer remain undefined.Peng ZhangAlice L. KwonChristina GuzzoQingbo LiuHana SchmeisserHuiyi MiaoYin LinRaffaello CimbroJinghe HuangMark ConnorsStephen D. SchmidtMichael A. DolanAnthony A. ArmstrongPaolo LussoAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 2 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Microbiology QR1-502 |
| spellingShingle |
Microbiology QR1-502 Peng Zhang Alice L. Kwon Christina Guzzo Qingbo Liu Hana Schmeisser Huiyi Miao Yin Lin Raffaello Cimbro Jinghe Huang Mark Connors Stephen D. Schmidt Michael A. Dolan Anthony A. Armstrong Paolo Lusso Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State |
| description |
Elucidating the structure and function of the HIV-1 outer envelope proteins is critical for the design of an effective vaccine. Despite the availability of many high-resolution structures, key functional correlates in the envelope trimer remain undefined. |
| format |
article |
| author |
Peng Zhang Alice L. Kwon Christina Guzzo Qingbo Liu Hana Schmeisser Huiyi Miao Yin Lin Raffaello Cimbro Jinghe Huang Mark Connors Stephen D. Schmidt Michael A. Dolan Anthony A. Armstrong Paolo Lusso |
| author_facet |
Peng Zhang Alice L. Kwon Christina Guzzo Qingbo Liu Hana Schmeisser Huiyi Miao Yin Lin Raffaello Cimbro Jinghe Huang Mark Connors Stephen D. Schmidt Michael A. Dolan Anthony A. Armstrong Paolo Lusso |
| author_sort |
Peng Zhang |
| title |
Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State |
| title_short |
Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State |
| title_full |
Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State |
| title_fullStr |
Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State |
| title_full_unstemmed |
Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State |
| title_sort |
functional anatomy of the trimer apex reveals key hydrophobic constraints that maintain the hiv-1 envelope spike in a closed state |
| publisher |
American Society for Microbiology |
| publishDate |
2021 |
| url |
https://doaj.org/article/b7ce808852144799b0fcfef045f0734b |
| work_keys_str_mv |
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| _version_ |
1718445416861663232 |