Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson’s Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment

Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson’s Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment

BackgroundNeuroinflammation and mitochondrial impairment play important roles in the neuropathogenesis of Parkinson’s disease (PD). The activation of NLRP3 inflammasome and the accumulation of α-synuclein (α-Syn) are strictly correlated to neuroinflammation. Therefore, the regulation of NLRP3 inflam...

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Bibliographic Details
Main Authors: Rongfang Que, Jialing Zheng, Zihan Chang, Wenjie Zhang, Hualing Li, Zhenchao Xie, Zifeng Huang, Hai-Tao Wang, Jiangping Xu, Dana Jin, Wanlin Yang, Eng-King Tan, Qing Wang
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
Parkinson’s disease
dl-3-n-Butylphthalide
NLRP3 inflammasome
neuroinflammation
α-Synuclein
PARP1
Immunologic diseases. Allergy
RC581-607
Online Access:https://doaj.org/article/b7d5643e59ba4472b6f50778febfc8f8
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https://doaj.org/article/b7d5643e59ba4472b6f50778febfc8f8

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