Intratumoral heterogeneity and clonal evolution in liver cancer

Intratumoral heterogeneity and clonal evolution in liver cancer

Immune-mediated selection pressures impact the clonal evolution of tumours. Here, in hepatocellular carcinoma the authors map spatio-temporal interactions between tumor and immune cells, highlighting the regulatory substrate of intra-tumoural heterogeneity that correlates with regional adaptive immu...

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Autores principales: Bojan Losic, Amanda J. Craig, Carlos Villacorta-Martin, Sebastiao N. Martins-Filho, Nicholas Akers, Xintong Chen, Mehmet E. Ahsen, Johann von Felden, Ismail Labgaa, Delia DʹAvola, Kimaada Allette, Sergio A. Lira, Glaucia C. Furtado, Teresa Garcia-Lezana, Paula Restrepo, Ashley Stueck, Stephen C. Ward, Maria I. Fiel, Spiros P. Hiotis, Ganesh Gunasekaran, Daniela Sia, Eric E. Schadt, Robert Sebra, Myron Schwartz, Josep M. Llovet, Swan Thung, Gustavo Stolovitzky, Augusto Villanueva
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b7e9387e6d0443a18b41f98ca9cd0d20
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spelling oai:doaj.org-article:b7e9387e6d0443a18b41f98ca9cd0d202021-12-02T14:40:51ZIntratumoral heterogeneity and clonal evolution in liver cancer10.1038/s41467-019-14050-z2041-1723https://doaj.org/article/b7e9387e6d0443a18b41f98ca9cd0d202020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14050-zhttps://doaj.org/toc/2041-1723Immune-mediated selection pressures impact the clonal evolution of tumours. Here, in hepatocellular carcinoma the authors map spatio-temporal interactions between tumor and immune cells, highlighting the regulatory substrate of intra-tumoural heterogeneity that correlates with regional adaptive immune responses.Bojan LosicAmanda J. CraigCarlos Villacorta-MartinSebastiao N. Martins-FilhoNicholas AkersXintong ChenMehmet E. AhsenJohann von FeldenIsmail LabgaaDelia DʹAvolaKimaada AlletteSergio A. LiraGlaucia C. FurtadoTeresa Garcia-LezanaPaula RestrepoAshley StueckStephen C. WardMaria I. FielSpiros P. HiotisGanesh GunasekaranDaniela SiaEric E. SchadtRobert SebraMyron SchwartzJosep M. LlovetSwan ThungGustavo StolovitzkyAugusto VillanuevaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bojan Losic
Amanda J. Craig
Carlos Villacorta-Martin
Sebastiao N. Martins-Filho
Nicholas Akers
Xintong Chen
Mehmet E. Ahsen
Johann von Felden
Ismail Labgaa
Delia DʹAvola
Kimaada Allette
Sergio A. Lira
Glaucia C. Furtado
Teresa Garcia-Lezana
Paula Restrepo
Ashley Stueck
Stephen C. Ward
Maria I. Fiel
Spiros P. Hiotis
Ganesh Gunasekaran
Daniela Sia
Eric E. Schadt
Robert Sebra
Myron Schwartz
Josep M. Llovet
Swan Thung
Gustavo Stolovitzky
Augusto Villanueva
Intratumoral heterogeneity and clonal evolution in liver cancer
description Immune-mediated selection pressures impact the clonal evolution of tumours. Here, in hepatocellular carcinoma the authors map spatio-temporal interactions between tumor and immune cells, highlighting the regulatory substrate of intra-tumoural heterogeneity that correlates with regional adaptive immune responses.
format article
author Bojan Losic
Amanda J. Craig
Carlos Villacorta-Martin
Sebastiao N. Martins-Filho
Nicholas Akers
Xintong Chen
Mehmet E. Ahsen
Johann von Felden
Ismail Labgaa
Delia DʹAvola
Kimaada Allette
Sergio A. Lira
Glaucia C. Furtado
Teresa Garcia-Lezana
Paula Restrepo
Ashley Stueck
Stephen C. Ward
Maria I. Fiel
Spiros P. Hiotis
Ganesh Gunasekaran
Daniela Sia
Eric E. Schadt
Robert Sebra
Myron Schwartz
Josep M. Llovet
Swan Thung
Gustavo Stolovitzky
Augusto Villanueva
author_facet Bojan Losic
Amanda J. Craig
Carlos Villacorta-Martin
Sebastiao N. Martins-Filho
Nicholas Akers
Xintong Chen
Mehmet E. Ahsen
Johann von Felden
Ismail Labgaa
Delia DʹAvola
Kimaada Allette
Sergio A. Lira
Glaucia C. Furtado
Teresa Garcia-Lezana
Paula Restrepo
Ashley Stueck
Stephen C. Ward
Maria I. Fiel
Spiros P. Hiotis
Ganesh Gunasekaran
Daniela Sia
Eric E. Schadt
Robert Sebra
Myron Schwartz
Josep M. Llovet
Swan Thung
Gustavo Stolovitzky
Augusto Villanueva
author_sort Bojan Losic
title Intratumoral heterogeneity and clonal evolution in liver cancer
title_short Intratumoral heterogeneity and clonal evolution in liver cancer
title_full Intratumoral heterogeneity and clonal evolution in liver cancer
title_fullStr Intratumoral heterogeneity and clonal evolution in liver cancer
title_full_unstemmed Intratumoral heterogeneity and clonal evolution in liver cancer
title_sort intratumoral heterogeneity and clonal evolution in liver cancer
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/b7e9387e6d0443a18b41f98ca9cd0d20
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