Methylphenidate regulation of osteoclasts in a dose- and sex-dependent manner adversely affects skeletal mechanical integrity

Abstract Methylphenidate (MP) is the most prescribed psychostimulant for ADHD patients, with clinically demonstrated detrimental effects on bone quality, potentially leading to early onset osteoporosis and higher fracture risk. The underlying mechanism for the effects of MP on bone remains elusive....

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Autores principales: Sardar M. Z. Uddin, Lisa S. Robison, Dennis Fricke, Evan Chernoff, Michael Hadjiargyrou, Panayotis K. Thanos, David E. Komatsu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/b7f2c753519745f3a0ae61e2cf991894
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