Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach

How a precancerous form (dysplasia) becomes gastric cancer is unclear. Here, the authors assess the role of Kras activation in heterogenous dysplastic cells in murine stomach corpus organoids, identifying two dysplastic stem cell populations and show that MEK inhibition causes alterations in cell be...

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Autores principales:	Jimin Min, Paige N. Vega, Amy C. Engevik, Janice A. Williams, Qing Yang, Loraine M. Patterson, Alan J. Simmons, R. Jarrett Bliton, Joshua W. Betts, Ken S. Lau, Scott T. Magness, James R. Goldenring, Eunyoung Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b7f6044c24154289a8aced09b8c59729
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spelling	oai:doaj.org-article:b7f6044c24154289a8aced09b8c597292021-12-02T16:58:16ZHeterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach10.1038/s41467-019-13479-62041-1723https://doaj.org/article/b7f6044c24154289a8aced09b8c597292019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13479-6https://doaj.org/toc/2041-1723How a precancerous form (dysplasia) becomes gastric cancer is unclear. Here, the authors assess the role of Kras activation in heterogenous dysplastic cells in murine stomach corpus organoids, identifying two dysplastic stem cell populations and show that MEK inhibition causes alterations in cell behavior.Jimin MinPaige N. VegaAmy C. EngevikJanice A. WilliamsQing YangLoraine M. PattersonAlan J. SimmonsR. Jarrett BlitonJoshua W. BettsKen S. LauScott T. MagnessJames R. GoldenringEunyoung ChoiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jimin Min Paige N. Vega Amy C. Engevik Janice A. Williams Qing Yang Loraine M. Patterson Alan J. Simmons R. Jarrett Bliton Joshua W. Betts Ken S. Lau Scott T. Magness James R. Goldenring Eunyoung Choi Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach
description	How a precancerous form (dysplasia) becomes gastric cancer is unclear. Here, the authors assess the role of Kras activation in heterogenous dysplastic cells in murine stomach corpus organoids, identifying two dysplastic stem cell populations and show that MEK inhibition causes alterations in cell behavior.
format	article
author	Jimin Min Paige N. Vega Amy C. Engevik Janice A. Williams Qing Yang Loraine M. Patterson Alan J. Simmons R. Jarrett Bliton Joshua W. Betts Ken S. Lau Scott T. Magness James R. Goldenring Eunyoung Choi
author_facet	Jimin Min Paige N. Vega Amy C. Engevik Janice A. Williams Qing Yang Loraine M. Patterson Alan J. Simmons R. Jarrett Bliton Joshua W. Betts Ken S. Lau Scott T. Magness James R. Goldenring Eunyoung Choi
author_sort	Jimin Min
title	Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach
title_short	Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach
title_full	Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach
title_fullStr	Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach
title_full_unstemmed	Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach
title_sort	heterogeneity and dynamics of active kras-induced dysplastic lineages from mouse corpus stomach
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b7f6044c24154289a8aced09b8c59729
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Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach

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