Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes

Abstract Glioblastoma (GBM) is one of the most aggressive types of cancer, which begins within the brain. It is the most invasive type of glioma developed from astrocytes. Until today, Temozolomide (TMZ) is the only standard chemotherapy for patients with GBM. Even though chemotherapy extends the su...

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Autores principales:	Ezeddine Harmouch, Joseph Seitlinger, Hassan Chaddad, Geneviève Ubeaud-Sequier, Jochen Barths, Sani Saidu, Laurent Désaubry, Stéphanie Grandemange, Thierry Massfelder, Guy Fuhrmann, Florence Fioretti, Monique Dontenwill, Nadia Benkirane-Jessel, Ysia Idoux-Gillet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b7f71d227f1e45b69f1e97f821dc7517
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spelling	oai:doaj.org-article:b7f71d227f1e45b69f1e97f821dc75172021-12-02T18:50:55ZFlavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes10.1038/s41598-020-70820-62045-2322https://doaj.org/article/b7f71d227f1e45b69f1e97f821dc75172020-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-70820-6https://doaj.org/toc/2045-2322Abstract Glioblastoma (GBM) is one of the most aggressive types of cancer, which begins within the brain. It is the most invasive type of glioma developed from astrocytes. Until today, Temozolomide (TMZ) is the only standard chemotherapy for patients with GBM. Even though chemotherapy extends the survival of patients, there are many undesirable side effects, and most cases show resistance to TMZ. FL3 is a synthetic flavagline which displays potent anticancer activities, and is known to inhibit cell proliferation, by provoking cell cycle arrest, and leads to apoptosis in a lot of cancer cell lines. However, the effect of FL3 in glioblastoma cancer cells has not yet been examined. Hypoxia is a major problem for patients with GBM, resulting in tumor resistance and aggressiveness. In this study, we explore the effect of FL3 in glioblastoma cells under normoxia and hypoxia conditions. Our results clearly indicate that this synthetic flavagline inhibits cell proliferation and induced senescence in glioblastoma cells cultured under both conditions. In addition, FL3 treatment had no effect on human brain astrocytes. These findings support the notion that the FL3 molecule could be used in combination with other chemotherapeutic agents or other therapies in glioblastoma treatments.Ezeddine HarmouchJoseph SeitlingerHassan ChaddadGeneviève Ubeaud-SequierJochen BarthsSani SaiduLaurent DésaubryStéphanie GrandemangeThierry MassfelderGuy FuhrmannFlorence FiorettiMonique DontenwillNadia Benkirane-JesselYsia Idoux-GilletNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ezeddine Harmouch Joseph Seitlinger Hassan Chaddad Geneviève Ubeaud-Sequier Jochen Barths Sani Saidu Laurent Désaubry Stéphanie Grandemange Thierry Massfelder Guy Fuhrmann Florence Fioretti Monique Dontenwill Nadia Benkirane-Jessel Ysia Idoux-Gillet Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes
description	Abstract Glioblastoma (GBM) is one of the most aggressive types of cancer, which begins within the brain. It is the most invasive type of glioma developed from astrocytes. Until today, Temozolomide (TMZ) is the only standard chemotherapy for patients with GBM. Even though chemotherapy extends the survival of patients, there are many undesirable side effects, and most cases show resistance to TMZ. FL3 is a synthetic flavagline which displays potent anticancer activities, and is known to inhibit cell proliferation, by provoking cell cycle arrest, and leads to apoptosis in a lot of cancer cell lines. However, the effect of FL3 in glioblastoma cancer cells has not yet been examined. Hypoxia is a major problem for patients with GBM, resulting in tumor resistance and aggressiveness. In this study, we explore the effect of FL3 in glioblastoma cells under normoxia and hypoxia conditions. Our results clearly indicate that this synthetic flavagline inhibits cell proliferation and induced senescence in glioblastoma cells cultured under both conditions. In addition, FL3 treatment had no effect on human brain astrocytes. These findings support the notion that the FL3 molecule could be used in combination with other chemotherapeutic agents or other therapies in glioblastoma treatments.
format	article
author	Ezeddine Harmouch Joseph Seitlinger Hassan Chaddad Geneviève Ubeaud-Sequier Jochen Barths Sani Saidu Laurent Désaubry Stéphanie Grandemange Thierry Massfelder Guy Fuhrmann Florence Fioretti Monique Dontenwill Nadia Benkirane-Jessel Ysia Idoux-Gillet
author_facet	Ezeddine Harmouch Joseph Seitlinger Hassan Chaddad Geneviève Ubeaud-Sequier Jochen Barths Sani Saidu Laurent Désaubry Stéphanie Grandemange Thierry Massfelder Guy Fuhrmann Florence Fioretti Monique Dontenwill Nadia Benkirane-Jessel Ysia Idoux-Gillet
author_sort	Ezeddine Harmouch
title	Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes
title_short	Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes
title_full	Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes
title_fullStr	Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes
title_full_unstemmed	Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes
title_sort	flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b7f71d227f1e45b69f1e97f821dc7517
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Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes

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