Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles

Ring-opening reaction via selective cleavage of C–C bond is a powerful strategy to increase molecular complexity. Here the authors present the facile synthesis of chiral 1,5- and 1,6-dinitriles via the radical-mediated ring-opening and enantioselective cyanation of cycloketone oxime esters.

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Autores principales: Tao Wang, Yi-Ning Wang, Rui Wang, Bo-Chao Zhang, Chi Yang, Yan-Lin Li, Xi-Sheng Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/b82b8cd2c3604c3785954d336db962f0
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