Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles

Ring-opening reaction via selective cleavage of C–C bond is a powerful strategy to increase molecular complexity. Here the authors present the facile synthesis of chiral 1,5- and 1,6-dinitriles via the radical-mediated ring-opening and enantioselective cyanation of cycloketone oxime esters.

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Autores principales:	Tao Wang, Yi-Ning Wang, Rui Wang, Bo-Chao Zhang, Chi Yang, Yan-Lin Li, Xi-Sheng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b82b8cd2c3604c3785954d336db962f0
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spelling	oai:doaj.org-article:b82b8cd2c3604c3785954d336db962f02021-12-02T17:01:51ZEnantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles10.1038/s41467-019-13369-x2041-1723https://doaj.org/article/b82b8cd2c3604c3785954d336db962f02019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13369-xhttps://doaj.org/toc/2041-1723Ring-opening reaction via selective cleavage of C–C bond is a powerful strategy to increase molecular complexity. Here the authors present the facile synthesis of chiral 1,5- and 1,6-dinitriles via the radical-mediated ring-opening and enantioselective cyanation of cycloketone oxime esters.Tao WangYi-Ning WangRui WangBo-Chao ZhangChi YangYan-Lin LiXi-Sheng WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tao Wang Yi-Ning Wang Rui Wang Bo-Chao Zhang Chi Yang Yan-Lin Li Xi-Sheng Wang Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles
description	Ring-opening reaction via selective cleavage of C–C bond is a powerful strategy to increase molecular complexity. Here the authors present the facile synthesis of chiral 1,5- and 1,6-dinitriles via the radical-mediated ring-opening and enantioselective cyanation of cycloketone oxime esters.
format	article
author	Tao Wang Yi-Ning Wang Rui Wang Bo-Chao Zhang Chi Yang Yan-Lin Li Xi-Sheng Wang
author_facet	Tao Wang Yi-Ning Wang Rui Wang Bo-Chao Zhang Chi Yang Yan-Lin Li Xi-Sheng Wang
author_sort	Tao Wang
title	Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles
title_short	Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles
title_full	Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles
title_fullStr	Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles
title_full_unstemmed	Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles
title_sort	enantioselective cyanation via radical-mediated c–c single bond cleavage for synthesis of chiral dinitriles
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b82b8cd2c3604c3785954d336db962f0
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Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles

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