High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human

Millions of enhancers are predicted, but their validation remains challenging. Here, the authors report genome-wide enhancer function quantification and high-resolution dissection for millions of accessible DNA fragments, revealing driver nucleotides and helping interpret non-coding disease variants...

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Bibliographic Details
Main Authors: Xinchen Wang, Liang He, Sarah M. Goggin, Alham Saadat, Li Wang, Nasa Sinnott-Armstrong, Melina Claussnitzer, Manolis Kellis
Format: article
Language:EN
Published: Nature Portfolio 2018
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Online Access:https://doaj.org/article/b840b6fe3d734ff1922a52f00577dac1
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