Selective inhibition of human translation termination by a drug-like compound

The drug-like compound PF846 and its derivatives inhibit the translation of specific mRNAs by the human ribosome. Here the authors show how PF846 arrests translation at the stop codon by slowing hydrolysis of the protein nascent chain at the ribosome P-site tRNA by eukaryotic release factor 1 (eRF1)...

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Auteurs principaux: Wenfei Li, Stacey Tsai-Lan Chang, Fred. R. Ward, Jamie H. D. Cate
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/b86e399a4ec045d89db7d9e3ea9c2b22
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