Selective inhibition of human translation termination by a drug-like compound

The drug-like compound PF846 and its derivatives inhibit the translation of specific mRNAs by the human ribosome. Here the authors show how PF846 arrests translation at the stop codon by slowing hydrolysis of the protein nascent chain at the ribosome P-site tRNA by eukaryotic release factor 1 (eRF1)...

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Autores principales:	Wenfei Li, Stacey Tsai-Lan Chang, Fred. R. Ward, Jamie H. D. Cate
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b86e399a4ec045d89db7d9e3ea9c2b22
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spelling	oai:doaj.org-article:b86e399a4ec045d89db7d9e3ea9c2b222021-12-02T17:18:08ZSelective inhibition of human translation termination by a drug-like compound10.1038/s41467-020-18765-22041-1723https://doaj.org/article/b86e399a4ec045d89db7d9e3ea9c2b222020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18765-2https://doaj.org/toc/2041-1723The drug-like compound PF846 and its derivatives inhibit the translation of specific mRNAs by the human ribosome. Here the authors show how PF846 arrests translation at the stop codon by slowing hydrolysis of the protein nascent chain at the ribosome P-site tRNA by eukaryotic release factor 1 (eRF1).Wenfei LiStacey Tsai-Lan ChangFred. R. WardJamie H. D. CateNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenfei Li Stacey Tsai-Lan Chang Fred. R. Ward Jamie H. D. Cate Selective inhibition of human translation termination by a drug-like compound
description	The drug-like compound PF846 and its derivatives inhibit the translation of specific mRNAs by the human ribosome. Here the authors show how PF846 arrests translation at the stop codon by slowing hydrolysis of the protein nascent chain at the ribosome P-site tRNA by eukaryotic release factor 1 (eRF1).
format	article
author	Wenfei Li Stacey Tsai-Lan Chang Fred. R. Ward Jamie H. D. Cate
author_facet	Wenfei Li Stacey Tsai-Lan Chang Fred. R. Ward Jamie H. D. Cate
author_sort	Wenfei Li
title	Selective inhibition of human translation termination by a drug-like compound
title_short	Selective inhibition of human translation termination by a drug-like compound
title_full	Selective inhibition of human translation termination by a drug-like compound
title_fullStr	Selective inhibition of human translation termination by a drug-like compound
title_full_unstemmed	Selective inhibition of human translation termination by a drug-like compound
title_sort	selective inhibition of human translation termination by a drug-like compound
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b86e399a4ec045d89db7d9e3ea9c2b22
work_keys_str_mv	AT wenfeili selectiveinhibitionofhumantranslationterminationbyadruglikecompound AT staceytsailanchang selectiveinhibitionofhumantranslationterminationbyadruglikecompound AT fredrward selectiveinhibitionofhumantranslationterminationbyadruglikecompound AT jamiehdcate selectiveinhibitionofhumantranslationterminationbyadruglikecompound
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Selective inhibition of human translation termination by a drug-like compound

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