Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis

The effects of mechanical forces, generated by actomyosin contractility, on E-cadherin based cell adhesion are poorly characterized in vivo. Here, the authors report that normal stress increases E-cadherin levels, whereas shear stress reduces E-Cadherin levels, in the developing Drosophila embryo.

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Autores principales:	Girish R. Kale, Xingbo Yang, Jean-Marc Philippe, Madhav Mani, Pierre-François Lenne, Thomas Lecuit
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b87a16a3ae16427ab429b68ab38c5d05
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spelling	oai:doaj.org-article:b87a16a3ae16427ab429b68ab38c5d052021-12-02T15:34:39ZDistinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis10.1038/s41467-018-07448-82041-1723https://doaj.org/article/b87a16a3ae16427ab429b68ab38c5d052018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07448-8https://doaj.org/toc/2041-1723The effects of mechanical forces, generated by actomyosin contractility, on E-cadherin based cell adhesion are poorly characterized in vivo. Here, the authors report that normal stress increases E-cadherin levels, whereas shear stress reduces E-Cadherin levels, in the developing Drosophila embryo.Girish R. KaleXingbo YangJean-Marc PhilippeMadhav ManiPierre-François LenneThomas LecuitNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Girish R. Kale Xingbo Yang Jean-Marc Philippe Madhav Mani Pierre-François Lenne Thomas Lecuit Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis
description	The effects of mechanical forces, generated by actomyosin contractility, on E-cadherin based cell adhesion are poorly characterized in vivo. Here, the authors report that normal stress increases E-cadherin levels, whereas shear stress reduces E-Cadherin levels, in the developing Drosophila embryo.
format	article
author	Girish R. Kale Xingbo Yang Jean-Marc Philippe Madhav Mani Pierre-François Lenne Thomas Lecuit
author_facet	Girish R. Kale Xingbo Yang Jean-Marc Philippe Madhav Mani Pierre-François Lenne Thomas Lecuit
author_sort	Girish R. Kale
title	Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis
title_short	Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis
title_full	Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis
title_fullStr	Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis
title_full_unstemmed	Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis
title_sort	distinct contributions of tensile and shear stress on e-cadherin levels during morphogenesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b87a16a3ae16427ab429b68ab38c5d05
work_keys_str_mv	AT girishrkale distinctcontributionsoftensileandshearstressonecadherinlevelsduringmorphogenesis AT xingboyang distinctcontributionsoftensileandshearstressonecadherinlevelsduringmorphogenesis AT jeanmarcphilippe distinctcontributionsoftensileandshearstressonecadherinlevelsduringmorphogenesis AT madhavmani distinctcontributionsoftensileandshearstressonecadherinlevelsduringmorphogenesis AT pierrefrancoislenne distinctcontributionsoftensileandshearstressonecadherinlevelsduringmorphogenesis AT thomaslecuit distinctcontributionsoftensileandshearstressonecadherinlevelsduringmorphogenesis
_version_	1718386801794613248

Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis

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