Anti-Inflammatory Effects of Novel <i>Glycyrrhiza</i> Variety Wongam In Vivo and In Vitro
Licorice is the common name of <i>Glycyrrhiza</i> species, which is an important plant for edible and medicinal purposes; however, <i>Glycyrrhiza</i> resources have become limited because of desertification, depletion of natural resources, and environmental restrictions. For...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/b87de06cb1f84eeea44510a429a39fa2 |
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| Sumario: | Licorice is the common name of <i>Glycyrrhiza</i> species, which is an important plant for edible and medicinal purposes; however, <i>Glycyrrhiza</i> resources have become limited because of desertification, depletion of natural resources, and environmental restrictions. For this reason, a novel <i>Glycyrrhiza</i> variety named Wongam, a hybrid of <i>G. glabra</i> and <i>G. uralensis</i>, was developed by the Korea Rural Development Administration. To elucidate the antiallergic inflammatory effects of Wongam, we investigated its effects using a compound-48/80-induced anaphylaxis in vivo model and PMA/A23187-stimulated HMC-1 cells and immunoglobulin E (IgE)/DNP-stimulated RBL-2H3 cells in in vitro models. Wongam treatment reduced mortality and serum IgE levels and downregulated proinflammatory cytokines and chemokines in a compound-48/80-induced anaphylaxis mouse model. Wongam decreased histamine release and the expression of proinflammatory cytokines in HMC-1 and RBL-2H3 cells. Wongam treatment downregulated the expression of chemokines, T helper 2 cytokines, and cell surface antigens in PMA/A23187-stimulated HMC-1 cells. We confirmed that these effects were associated with the inhibition of the MAPK and NF-κB signaling pathways by Wongam. The present study suggests that Wongam ameliorates mast-cell-mediated allergic inflammatory responses by reducing mast cell activation and may serve as an effective agent for the prevention and treatment of allergic inflammatory responses. |
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