Anti-Inflammatory Effects of Novel Glycyrrhiza Variety Wongam In Vivo and In Vitro

Licorice is the common name of Glycyrrhiza species, which is an important plant for edible and medicinal purposes; however, Glycyrrhiza resources have become limited because of desertification, depletion of natural resources, and environmental restrictions. For...

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Autores principales:	Yun-Mi Kang, Jeonghoon Lee, Wonnam Kim, Jong-Sik Jin, Jong-Hyun Lee, Hyo-Jin An
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	allergy inflammation novel <i>Glycyrrhiza</i> varieties Wongam mast cell activation anaphylaxis Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b87de06cb1f84eeea44510a429a39fa2
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spelling	oai:doaj.org-article:b87de06cb1f84eeea44510a429a39fa22021-11-25T16:39:02ZAnti-Inflammatory Effects of Novel <i>Glycyrrhiza</i> Variety Wongam In Vivo and In Vitro10.3390/app1122108222076-3417https://doaj.org/article/b87de06cb1f84eeea44510a429a39fa22021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10822https://doaj.org/toc/2076-3417Licorice is the common name of <i>Glycyrrhiza</i> species, which is an important plant for edible and medicinal purposes; however, <i>Glycyrrhiza</i> resources have become limited because of desertification, depletion of natural resources, and environmental restrictions. For this reason, a novel <i>Glycyrrhiza</i> variety named Wongam, a hybrid of <i>G. glabra</i> and <i>G. uralensis</i>, was developed by the Korea Rural Development Administration. To elucidate the antiallergic inflammatory effects of Wongam, we investigated its effects using a compound-48/80-induced anaphylaxis in vivo model and PMA/A23187-stimulated HMC-1 cells and immunoglobulin E (IgE)/DNP-stimulated RBL-2H3 cells in in vitro models. Wongam treatment reduced mortality and serum IgE levels and downregulated proinflammatory cytokines and chemokines in a compound-48/80-induced anaphylaxis mouse model. Wongam decreased histamine release and the expression of proinflammatory cytokines in HMC-1 and RBL-2H3 cells. Wongam treatment downregulated the expression of chemokines, T helper 2 cytokines, and cell surface antigens in PMA/A23187-stimulated HMC-1 cells. We confirmed that these effects were associated with the inhibition of the MAPK and NF-κB signaling pathways by Wongam. The present study suggests that Wongam ameliorates mast-cell-mediated allergic inflammatory responses by reducing mast cell activation and may serve as an effective agent for the prevention and treatment of allergic inflammatory responses.Yun-Mi KangJeonghoon LeeWonnam KimJong-Sik JinJong-Hyun LeeHyo-Jin AnMDPI AGarticleallergyinflammationnovel <i>Glycyrrhiza</i> varietiesWongammast cell activationanaphylaxisTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10822, p 10822 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	allergy inflammation novel <i>Glycyrrhiza</i> varieties Wongam mast cell activation anaphylaxis Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	allergy inflammation novel <i>Glycyrrhiza</i> varieties Wongam mast cell activation anaphylaxis Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Yun-Mi Kang Jeonghoon Lee Wonnam Kim Jong-Sik Jin Jong-Hyun Lee Hyo-Jin An Anti-Inflammatory Effects of Novel <i>Glycyrrhiza</i> Variety Wongam In Vivo and In Vitro
description	Licorice is the common name of <i>Glycyrrhiza</i> species, which is an important plant for edible and medicinal purposes; however, <i>Glycyrrhiza</i> resources have become limited because of desertification, depletion of natural resources, and environmental restrictions. For this reason, a novel <i>Glycyrrhiza</i> variety named Wongam, a hybrid of <i>G. glabra</i> and <i>G. uralensis</i>, was developed by the Korea Rural Development Administration. To elucidate the antiallergic inflammatory effects of Wongam, we investigated its effects using a compound-48/80-induced anaphylaxis in vivo model and PMA/A23187-stimulated HMC-1 cells and immunoglobulin E (IgE)/DNP-stimulated RBL-2H3 cells in in vitro models. Wongam treatment reduced mortality and serum IgE levels and downregulated proinflammatory cytokines and chemokines in a compound-48/80-induced anaphylaxis mouse model. Wongam decreased histamine release and the expression of proinflammatory cytokines in HMC-1 and RBL-2H3 cells. Wongam treatment downregulated the expression of chemokines, T helper 2 cytokines, and cell surface antigens in PMA/A23187-stimulated HMC-1 cells. We confirmed that these effects were associated with the inhibition of the MAPK and NF-κB signaling pathways by Wongam. The present study suggests that Wongam ameliorates mast-cell-mediated allergic inflammatory responses by reducing mast cell activation and may serve as an effective agent for the prevention and treatment of allergic inflammatory responses.
format	article
author	Yun-Mi Kang Jeonghoon Lee Wonnam Kim Jong-Sik Jin Jong-Hyun Lee Hyo-Jin An
author_facet	Yun-Mi Kang Jeonghoon Lee Wonnam Kim Jong-Sik Jin Jong-Hyun Lee Hyo-Jin An
author_sort	Yun-Mi Kang
title	Anti-Inflammatory Effects of Novel <i>Glycyrrhiza</i> Variety Wongam In Vivo and In Vitro
title_short	Anti-Inflammatory Effects of Novel <i>Glycyrrhiza</i> Variety Wongam In Vivo and In Vitro
title_full	Anti-Inflammatory Effects of Novel <i>Glycyrrhiza</i> Variety Wongam In Vivo and In Vitro
title_fullStr	Anti-Inflammatory Effects of Novel <i>Glycyrrhiza</i> Variety Wongam In Vivo and In Vitro
title_full_unstemmed	Anti-Inflammatory Effects of Novel <i>Glycyrrhiza</i> Variety Wongam In Vivo and In Vitro
title_sort	anti-inflammatory effects of novel <i>glycyrrhiza</i> variety wongam in vivo and in vitro
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b87de06cb1f84eeea44510a429a39fa2
work_keys_str_mv	AT yunmikang antiinflammatoryeffectsofnoveliglycyrrhizaivarietywongaminvivoandinvitro AT jeonghoonlee antiinflammatoryeffectsofnoveliglycyrrhizaivarietywongaminvivoandinvitro AT wonnamkim antiinflammatoryeffectsofnoveliglycyrrhizaivarietywongaminvivoandinvitro AT jongsikjin antiinflammatoryeffectsofnoveliglycyrrhizaivarietywongaminvivoandinvitro AT jonghyunlee antiinflammatoryeffectsofnoveliglycyrrhizaivarietywongaminvivoandinvitro AT hyojinan antiinflammatoryeffectsofnoveliglycyrrhizaivarietywongaminvivoandinvitro
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Anti-Inflammatory Effects of Novel <i>Glycyrrhiza</i> Variety Wongam In Vivo and In Vitro

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