Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90

The chaperone Hsp90 uses the free energy from ATP hydrolysis to control the folding of client proteins in eukaryotic cells. Here the authors provide mechanistic insights into how its catalytic activity is coupled to conformational changes by combining large-scale molecular simulations with NMR, FRET...

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Autores principales:	Sophie L. Mader, Abraham Lopez, Jannis Lawatscheck, Qi Luo, Daniel A. Rutz, Ana P. Gamiz-Hernandez, Michael Sattler, Johannes Buchner, Ville R. I. Kaila
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b87ff0e02f1548cc99bb836c5ec50ea7
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spelling	oai:doaj.org-article:b87ff0e02f1548cc99bb836c5ec50ea72021-12-02T16:49:14ZConformational dynamics modulate the catalytic activity of the molecular chaperone Hsp9010.1038/s41467-020-15050-02041-1723https://doaj.org/article/b87ff0e02f1548cc99bb836c5ec50ea72020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15050-0https://doaj.org/toc/2041-1723The chaperone Hsp90 uses the free energy from ATP hydrolysis to control the folding of client proteins in eukaryotic cells. Here the authors provide mechanistic insights into how its catalytic activity is coupled to conformational changes by combining large-scale molecular simulations with NMR, FRET and SAXS experiments.Sophie L. MaderAbraham LopezJannis LawatscheckQi LuoDaniel A. RutzAna P. Gamiz-HernandezMichael SattlerJohannes BuchnerVille R. I. KailaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sophie L. Mader Abraham Lopez Jannis Lawatscheck Qi Luo Daniel A. Rutz Ana P. Gamiz-Hernandez Michael Sattler Johannes Buchner Ville R. I. Kaila Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90
description	The chaperone Hsp90 uses the free energy from ATP hydrolysis to control the folding of client proteins in eukaryotic cells. Here the authors provide mechanistic insights into how its catalytic activity is coupled to conformational changes by combining large-scale molecular simulations with NMR, FRET and SAXS experiments.
format	article
author	Sophie L. Mader Abraham Lopez Jannis Lawatscheck Qi Luo Daniel A. Rutz Ana P. Gamiz-Hernandez Michael Sattler Johannes Buchner Ville R. I. Kaila
author_facet	Sophie L. Mader Abraham Lopez Jannis Lawatscheck Qi Luo Daniel A. Rutz Ana P. Gamiz-Hernandez Michael Sattler Johannes Buchner Ville R. I. Kaila
author_sort	Sophie L. Mader
title	Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90
title_short	Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90
title_full	Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90
title_fullStr	Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90
title_full_unstemmed	Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90
title_sort	conformational dynamics modulate the catalytic activity of the molecular chaperone hsp90
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b87ff0e02f1548cc99bb836c5ec50ea7
work_keys_str_mv	AT sophielmader conformationaldynamicsmodulatethecatalyticactivityofthemolecularchaperonehsp90 AT abrahamlopez conformationaldynamicsmodulatethecatalyticactivityofthemolecularchaperonehsp90 AT jannislawatscheck conformationaldynamicsmodulatethecatalyticactivityofthemolecularchaperonehsp90 AT qiluo conformationaldynamicsmodulatethecatalyticactivityofthemolecularchaperonehsp90 AT danielarutz conformationaldynamicsmodulatethecatalyticactivityofthemolecularchaperonehsp90 AT anapgamizhernandez conformationaldynamicsmodulatethecatalyticactivityofthemolecularchaperonehsp90 AT michaelsattler conformationaldynamicsmodulatethecatalyticactivityofthemolecularchaperonehsp90 AT johannesbuchner conformationaldynamicsmodulatethecatalyticactivityofthemolecularchaperonehsp90 AT villerikaila conformationaldynamicsmodulatethecatalyticactivityofthemolecularchaperonehsp90
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Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90

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