A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

Ceramides are signalling molecules that regulate several physiological functions including insulin sensitivity. Here the authors report a selective ceramide synthase 1 inhibitor that counteracts lipid accumulation within the muscle and adiposity by increasing fatty acid oxidation but without affecti...

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Bibliographic Details
Main Authors: Nigel Turner, Xin Ying Lim, Hamish D. Toop, Brenna Osborne, Amanda E. Brandon, Elysha N. Taylor, Corrine E. Fiveash, Hemna Govindaraju, Jonathan D. Teo, Holly P. McEwen, Timothy A. Couttas, Stephen M. Butler, Abhirup Das, Greg M. Kowalski, Clinton R. Bruce, Kyle L. Hoehn, Thomas Fath, Carsten Schmitz-Peiffer, Gregory J. Cooney, Magdalene K. Montgomery, Jonathan C. Morris, Anthony S. Don
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
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Online Access:https://doaj.org/article/b889316af6b04ac29b1836b3ff8bcb97
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