FastClone is a probabilistic tool for deconvoluting tumor heterogeneity in bulk-sequencing samples

Multiple algorithms exist for predicting heterogeneity and clonal architecture from the bulk sequencing of tumor tissue. Here, the authors report on an algorithm, FastClone, which was developed from a DREAM challenge and show that FastClone can accurately predict clonality in simulated data and data...

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Autores principales:	Yao Xiao, Xueqing Wang, Hongjiu Zhang, Peter J. Ulintz, Hongyang Li, Yuanfang Guan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b8a8a985e0b94c83996a18132f1a4e60
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spelling	oai:doaj.org-article:b8a8a985e0b94c83996a18132f1a4e602021-12-02T19:12:30ZFastClone is a probabilistic tool for deconvoluting tumor heterogeneity in bulk-sequencing samples10.1038/s41467-020-18169-22041-1723https://doaj.org/article/b8a8a985e0b94c83996a18132f1a4e602020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18169-2https://doaj.org/toc/2041-1723Multiple algorithms exist for predicting heterogeneity and clonal architecture from the bulk sequencing of tumor tissue. Here, the authors report on an algorithm, FastClone, which was developed from a DREAM challenge and show that FastClone can accurately predict clonality in simulated data and data from colon cancer.Yao XiaoXueqing WangHongjiu ZhangPeter J. UlintzHongyang LiYuanfang GuanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yao Xiao Xueqing Wang Hongjiu Zhang Peter J. Ulintz Hongyang Li Yuanfang Guan FastClone is a probabilistic tool for deconvoluting tumor heterogeneity in bulk-sequencing samples
description	Multiple algorithms exist for predicting heterogeneity and clonal architecture from the bulk sequencing of tumor tissue. Here, the authors report on an algorithm, FastClone, which was developed from a DREAM challenge and show that FastClone can accurately predict clonality in simulated data and data from colon cancer.
format	article
author	Yao Xiao Xueqing Wang Hongjiu Zhang Peter J. Ulintz Hongyang Li Yuanfang Guan
author_facet	Yao Xiao Xueqing Wang Hongjiu Zhang Peter J. Ulintz Hongyang Li Yuanfang Guan
author_sort	Yao Xiao
title	FastClone is a probabilistic tool for deconvoluting tumor heterogeneity in bulk-sequencing samples
title_short	FastClone is a probabilistic tool for deconvoluting tumor heterogeneity in bulk-sequencing samples
title_full	FastClone is a probabilistic tool for deconvoluting tumor heterogeneity in bulk-sequencing samples
title_fullStr	FastClone is a probabilistic tool for deconvoluting tumor heterogeneity in bulk-sequencing samples
title_full_unstemmed	FastClone is a probabilistic tool for deconvoluting tumor heterogeneity in bulk-sequencing samples
title_sort	fastclone is a probabilistic tool for deconvoluting tumor heterogeneity in bulk-sequencing samples
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b8a8a985e0b94c83996a18132f1a4e60
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FastClone is a probabilistic tool for deconvoluting tumor heterogeneity in bulk-sequencing samples

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