Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies
Estimated glomerular filtration rate (eGFR) is a measure of kidney function used to define chronic kidney disease. Here, Morris et al. perform trans-ethnic genome-wide meta-analyses for eGFR in 312,468 individuals and identify novel loci and downstream putative causal genes.
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Nature Portfolio
2019
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oai:doaj.org-article:b8a9cf68600449b683542f422dc012d22021-12-02T17:01:26ZTrans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies10.1038/s41467-018-07867-72041-1723https://doaj.org/article/b8a9cf68600449b683542f422dc012d22019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07867-7https://doaj.org/toc/2041-1723Estimated glomerular filtration rate (eGFR) is a measure of kidney function used to define chronic kidney disease. Here, Morris et al. perform trans-ethnic genome-wide meta-analyses for eGFR in 312,468 individuals and identify novel loci and downstream putative causal genes.Andrew P. MorrisThu H. LeHaojia WuArtur AkbarovPeter J. van der MostGibran HemaniGeorge Davey SmithAnubha MahajanKyle J. GaultonGirish N. NadkarniAdan Valladares-SalgadoNiels Wacher-RodarteJosyf C. MychaleckyjNicole D. DuekerXiuqing GuoYang HaiJeffrey HaesslerYoichiro KamataniAdrienne M. StilpGu ZhuJames P. CookJohan ÄrnlövSusan H. BlantonMartin H. de BorstErwin P. BottingerThomas A. BuchananSylvia CechovaFadi J. CharcharPei-Lun ChuJeffrey DammanJames EalesAli G. GharaviVilmantas GiedraitisAndrew C. HeathEli IppKrzysztof KirylukHolly J. KramerMichiaki KuboAnders LarssonCecilia M. LindgrenYingchang LuPamela A. F. MaddenGrant W. MontgomeryGeorge J. PapanicolaouLeslie J. RaffelRalph L. SaccoElena SanchezHolger StarkJohan SundstromKent D. TaylorAnny H. XiangAleksandra ZivkovicLars LindErik IngelssonNicholas G. MartinJohn B. WhitfieldJianwen CaiCathy C. LaurieYukinori OkadaKoichi MatsudaCharles KooperbergYii-Der Ida ChenTatjana RundekStephen S. RichRuth J. F. LoosEsteban J. ParraMiguel CruzJerome I. RotterHarold SniederMaciej TomaszewskiBenjamin D. HumphreysNora FranceschiniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Andrew P. Morris Thu H. Le Haojia Wu Artur Akbarov Peter J. van der Most Gibran Hemani George Davey Smith Anubha Mahajan Kyle J. Gaulton Girish N. Nadkarni Adan Valladares-Salgado Niels Wacher-Rodarte Josyf C. Mychaleckyj Nicole D. Dueker Xiuqing Guo Yang Hai Jeffrey Haessler Yoichiro Kamatani Adrienne M. Stilp Gu Zhu James P. Cook Johan Ärnlöv Susan H. Blanton Martin H. de Borst Erwin P. Bottinger Thomas A. Buchanan Sylvia Cechova Fadi J. Charchar Pei-Lun Chu Jeffrey Damman James Eales Ali G. Gharavi Vilmantas Giedraitis Andrew C. Heath Eli Ipp Krzysztof Kiryluk Holly J. Kramer Michiaki Kubo Anders Larsson Cecilia M. Lindgren Yingchang Lu Pamela A. F. Madden Grant W. Montgomery George J. Papanicolaou Leslie J. Raffel Ralph L. Sacco Elena Sanchez Holger Stark Johan Sundstrom Kent D. Taylor Anny H. Xiang Aleksandra Zivkovic Lars Lind Erik Ingelsson Nicholas G. Martin John B. Whitfield Jianwen Cai Cathy C. Laurie Yukinori Okada Koichi Matsuda Charles Kooperberg Yii-Der Ida Chen Tatjana Rundek Stephen S. Rich Ruth J. F. Loos Esteban J. Parra Miguel Cruz Jerome I. Rotter Harold Snieder Maciej Tomaszewski Benjamin D. Humphreys Nora Franceschini Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies |
| description |
Estimated glomerular filtration rate (eGFR) is a measure of kidney function used to define chronic kidney disease. Here, Morris et al. perform trans-ethnic genome-wide meta-analyses for eGFR in 312,468 individuals and identify novel loci and downstream putative causal genes. |
| format |
article |
| author |
Andrew P. Morris Thu H. Le Haojia Wu Artur Akbarov Peter J. van der Most Gibran Hemani George Davey Smith Anubha Mahajan Kyle J. Gaulton Girish N. Nadkarni Adan Valladares-Salgado Niels Wacher-Rodarte Josyf C. Mychaleckyj Nicole D. Dueker Xiuqing Guo Yang Hai Jeffrey Haessler Yoichiro Kamatani Adrienne M. Stilp Gu Zhu James P. Cook Johan Ärnlöv Susan H. Blanton Martin H. de Borst Erwin P. Bottinger Thomas A. Buchanan Sylvia Cechova Fadi J. Charchar Pei-Lun Chu Jeffrey Damman James Eales Ali G. Gharavi Vilmantas Giedraitis Andrew C. Heath Eli Ipp Krzysztof Kiryluk Holly J. Kramer Michiaki Kubo Anders Larsson Cecilia M. Lindgren Yingchang Lu Pamela A. F. Madden Grant W. Montgomery George J. Papanicolaou Leslie J. Raffel Ralph L. Sacco Elena Sanchez Holger Stark Johan Sundstrom Kent D. Taylor Anny H. Xiang Aleksandra Zivkovic Lars Lind Erik Ingelsson Nicholas G. Martin John B. Whitfield Jianwen Cai Cathy C. Laurie Yukinori Okada Koichi Matsuda Charles Kooperberg Yii-Der Ida Chen Tatjana Rundek Stephen S. Rich Ruth J. F. Loos Esteban J. Parra Miguel Cruz Jerome I. Rotter Harold Snieder Maciej Tomaszewski Benjamin D. Humphreys Nora Franceschini |
| author_facet |
Andrew P. Morris Thu H. Le Haojia Wu Artur Akbarov Peter J. van der Most Gibran Hemani George Davey Smith Anubha Mahajan Kyle J. Gaulton Girish N. Nadkarni Adan Valladares-Salgado Niels Wacher-Rodarte Josyf C. Mychaleckyj Nicole D. Dueker Xiuqing Guo Yang Hai Jeffrey Haessler Yoichiro Kamatani Adrienne M. Stilp Gu Zhu James P. Cook Johan Ärnlöv Susan H. Blanton Martin H. de Borst Erwin P. Bottinger Thomas A. Buchanan Sylvia Cechova Fadi J. Charchar Pei-Lun Chu Jeffrey Damman James Eales Ali G. Gharavi Vilmantas Giedraitis Andrew C. Heath Eli Ipp Krzysztof Kiryluk Holly J. Kramer Michiaki Kubo Anders Larsson Cecilia M. Lindgren Yingchang Lu Pamela A. F. Madden Grant W. Montgomery George J. Papanicolaou Leslie J. Raffel Ralph L. Sacco Elena Sanchez Holger Stark Johan Sundstrom Kent D. Taylor Anny H. Xiang Aleksandra Zivkovic Lars Lind Erik Ingelsson Nicholas G. Martin John B. Whitfield Jianwen Cai Cathy C. Laurie Yukinori Okada Koichi Matsuda Charles Kooperberg Yii-Der Ida Chen Tatjana Rundek Stephen S. Rich Ruth J. F. Loos Esteban J. Parra Miguel Cruz Jerome I. Rotter Harold Snieder Maciej Tomaszewski Benjamin D. Humphreys Nora Franceschini |
| author_sort |
Andrew P. Morris |
| title |
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies |
| title_short |
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies |
| title_full |
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies |
| title_fullStr |
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies |
| title_full_unstemmed |
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies |
| title_sort |
trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/b8a9cf68600449b683542f422dc012d2 |
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