Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis

Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis

Ophiorrhiza pumila is a medicinal plant that can produce the anti-cancer monoterpene indole alkaloid (MIA) camptothecin. Here, the authors report its genome assembly and propose a working model for MIA evolution and biosynthesis through comparative genomics, synteny, and metabolic gene cluster analy...

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Autores principales: Amit Rai, Hideki Hirakawa, Ryo Nakabayashi, Shinji Kikuchi, Koki Hayashi, Megha Rai, Hiroshi Tsugawa, Taiki Nakaya, Tetsuya Mori, Hideki Nagasaki, Runa Fukushi, Yoko Kusuya, Hiroki Takahashi, Hiroshi Uchiyama, Atsushi Toyoda, Shoko Hikosaka, Eiji Goto, Kazuki Saito, Mami Yamazaki
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b8bd330113a948f992c2712a8064df69
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spelling oai:doaj.org-article:b8bd330113a948f992c2712a8064df692021-12-02T14:01:15ZChromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis10.1038/s41467-020-20508-22041-1723https://doaj.org/article/b8bd330113a948f992c2712a8064df692021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20508-2https://doaj.org/toc/2041-1723Ophiorrhiza pumila is a medicinal plant that can produce the anti-cancer monoterpene indole alkaloid (MIA) camptothecin. Here, the authors report its genome assembly and propose a working model for MIA evolution and biosynthesis through comparative genomics, synteny, and metabolic gene cluster analyses.Amit RaiHideki HirakawaRyo NakabayashiShinji KikuchiKoki HayashiMegha RaiHiroshi TsugawaTaiki NakayaTetsuya MoriHideki NagasakiRuna FukushiYoko KusuyaHiroki TakahashiHiroshi UchiyamaAtsushi ToyodaShoko HikosakaEiji GotoKazuki SaitoMami YamazakiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Amit Rai
Hideki Hirakawa
Ryo Nakabayashi
Shinji Kikuchi
Koki Hayashi
Megha Rai
Hiroshi Tsugawa
Taiki Nakaya
Tetsuya Mori
Hideki Nagasaki
Runa Fukushi
Yoko Kusuya
Hiroki Takahashi
Hiroshi Uchiyama
Atsushi Toyoda
Shoko Hikosaka
Eiji Goto
Kazuki Saito
Mami Yamazaki
Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis
description Ophiorrhiza pumila is a medicinal plant that can produce the anti-cancer monoterpene indole alkaloid (MIA) camptothecin. Here, the authors report its genome assembly and propose a working model for MIA evolution and biosynthesis through comparative genomics, synteny, and metabolic gene cluster analyses.
format article
author Amit Rai
Hideki Hirakawa
Ryo Nakabayashi
Shinji Kikuchi
Koki Hayashi
Megha Rai
Hiroshi Tsugawa
Taiki Nakaya
Tetsuya Mori
Hideki Nagasaki
Runa Fukushi
Yoko Kusuya
Hiroki Takahashi
Hiroshi Uchiyama
Atsushi Toyoda
Shoko Hikosaka
Eiji Goto
Kazuki Saito
Mami Yamazaki
author_facet Amit Rai
Hideki Hirakawa
Ryo Nakabayashi
Shinji Kikuchi
Koki Hayashi
Megha Rai
Hiroshi Tsugawa
Taiki Nakaya
Tetsuya Mori
Hideki Nagasaki
Runa Fukushi
Yoko Kusuya
Hiroki Takahashi
Hiroshi Uchiyama
Atsushi Toyoda
Shoko Hikosaka
Eiji Goto
Kazuki Saito
Mami Yamazaki
author_sort Amit Rai
title Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis
title_short Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis
title_full Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis
title_fullStr Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis
title_full_unstemmed Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis
title_sort chromosome-level genome assembly of ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/b8bd330113a948f992c2712a8064df69
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