Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility

Artemisinin (ART) resistance poses a problem for malaria elimination. Here, the authors perform genome-wide CRISPR screens in Toxoplasma gondii and identify that the putative transporter Tmem14c and mitochondrial heme metabolism, through mitochondrial protease DegP2, affect ART susceptibility.

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Autores principales:	Clare R. Harding, Saima M. Sidik, Boryana Petrova, Nina F. Gnädig, John Okombo, Alice L. Herneisen, Kurt E. Ward, Benedikt M. Markus, Elizabeth A. Boydston, David A. Fidock, Sebastian Lourido
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b8df34776e6545b698c1d120fc0d277b
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spelling	oai:doaj.org-article:b8df34776e6545b698c1d120fc0d277b2021-12-02T18:48:11ZGenetic screens reveal a central role for heme metabolism in artemisinin susceptibility10.1038/s41467-020-18624-02041-1723https://doaj.org/article/b8df34776e6545b698c1d120fc0d277b2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18624-0https://doaj.org/toc/2041-1723Artemisinin (ART) resistance poses a problem for malaria elimination. Here, the authors perform genome-wide CRISPR screens in Toxoplasma gondii and identify that the putative transporter Tmem14c and mitochondrial heme metabolism, through mitochondrial protease DegP2, affect ART susceptibility.Clare R. HardingSaima M. SidikBoryana PetrovaNina F. GnädigJohn OkomboAlice L. HerneisenKurt E. WardBenedikt M. MarkusElizabeth A. BoydstonDavid A. FidockSebastian LouridoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Clare R. Harding Saima M. Sidik Boryana Petrova Nina F. Gnädig John Okombo Alice L. Herneisen Kurt E. Ward Benedikt M. Markus Elizabeth A. Boydston David A. Fidock Sebastian Lourido Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility
description	Artemisinin (ART) resistance poses a problem for malaria elimination. Here, the authors perform genome-wide CRISPR screens in Toxoplasma gondii and identify that the putative transporter Tmem14c and mitochondrial heme metabolism, through mitochondrial protease DegP2, affect ART susceptibility.
format	article
author	Clare R. Harding Saima M. Sidik Boryana Petrova Nina F. Gnädig John Okombo Alice L. Herneisen Kurt E. Ward Benedikt M. Markus Elizabeth A. Boydston David A. Fidock Sebastian Lourido
author_facet	Clare R. Harding Saima M. Sidik Boryana Petrova Nina F. Gnädig John Okombo Alice L. Herneisen Kurt E. Ward Benedikt M. Markus Elizabeth A. Boydston David A. Fidock Sebastian Lourido
author_sort	Clare R. Harding
title	Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility
title_short	Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility
title_full	Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility
title_fullStr	Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility
title_full_unstemmed	Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility
title_sort	genetic screens reveal a central role for heme metabolism in artemisinin susceptibility
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b8df34776e6545b698c1d120fc0d277b
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Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility

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