A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance

Damaged mitochondria are normally cleared through canonical and alternative autophagy pathways. Here, the authors report that mitochondria can be cleared through an autophagy-independent endosomal-lysosomal pathway that depends on Parkin-dependent sequestration of mitochondria in Rab5-positive early...

Full description

Saved in:
Bibliographic Details
Main Authors: Babette C. Hammerling, Rita H. Najor, Melissa Q. Cortez, Sarah E. Shires, Leonardo J. Leon, Eileen R. Gonzalez, Daniela Boassa, Sébastien Phan, Andrea Thor, Rebecca E. Jimenez, Hong Li, Richard N. Kitsis, Gerald W. Dorn II, Junichi Sadoshima, Mark H. Ellisman, Åsa B. Gustafsson
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
Q
Online Access:https://doaj.org/article/b90a7538f1694e4281da0c789cbd7c2c
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/b90a7538f1694e4281da0c789cbd7c2c

Similar Items