A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance

Damaged mitochondria are normally cleared through canonical and alternative autophagy pathways. Here, the authors report that mitochondria can be cleared through an autophagy-independent endosomal-lysosomal pathway that depends on Parkin-dependent sequestration of mitochondria in Rab5-positive early...

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Autores principales:	Babette C. Hammerling, Rita H. Najor, Melissa Q. Cortez, Sarah E. Shires, Leonardo J. Leon, Eileen R. Gonzalez, Daniela Boassa, Sébastien Phan, Andrea Thor, Rebecca E. Jimenez, Hong Li, Richard N. Kitsis, Gerald W. Dorn II, Junichi Sadoshima, Mark H. Ellisman, Åsa B. Gustafsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b90a7538f1694e4281da0c789cbd7c2c
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spelling	oai:doaj.org-article:b90a7538f1694e4281da0c789cbd7c2c2021-12-02T14:40:56ZA Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance10.1038/ncomms140502041-1723https://doaj.org/article/b90a7538f1694e4281da0c789cbd7c2c2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14050https://doaj.org/toc/2041-1723Damaged mitochondria are normally cleared through canonical and alternative autophagy pathways. Here, the authors report that mitochondria can be cleared through an autophagy-independent endosomal-lysosomal pathway that depends on Parkin-dependent sequestration of mitochondria in Rab5-positive early endosomes.Babette C. HammerlingRita H. NajorMelissa Q. CortezSarah E. ShiresLeonardo J. LeonEileen R. GonzalezDaniela BoassaSébastien PhanAndrea ThorRebecca E. JimenezHong LiRichard N. KitsisGerald W. Dorn IIJunichi SadoshimaMark H. EllismanÅsa B. GustafssonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Babette C. Hammerling Rita H. Najor Melissa Q. Cortez Sarah E. Shires Leonardo J. Leon Eileen R. Gonzalez Daniela Boassa Sébastien Phan Andrea Thor Rebecca E. Jimenez Hong Li Richard N. Kitsis Gerald W. Dorn II Junichi Sadoshima Mark H. Ellisman Åsa B. Gustafsson A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance
description	Damaged mitochondria are normally cleared through canonical and alternative autophagy pathways. Here, the authors report that mitochondria can be cleared through an autophagy-independent endosomal-lysosomal pathway that depends on Parkin-dependent sequestration of mitochondria in Rab5-positive early endosomes.
format	article
author	Babette C. Hammerling Rita H. Najor Melissa Q. Cortez Sarah E. Shires Leonardo J. Leon Eileen R. Gonzalez Daniela Boassa Sébastien Phan Andrea Thor Rebecca E. Jimenez Hong Li Richard N. Kitsis Gerald W. Dorn II Junichi Sadoshima Mark H. Ellisman Åsa B. Gustafsson
author_facet	Babette C. Hammerling Rita H. Najor Melissa Q. Cortez Sarah E. Shires Leonardo J. Leon Eileen R. Gonzalez Daniela Boassa Sébastien Phan Andrea Thor Rebecca E. Jimenez Hong Li Richard N. Kitsis Gerald W. Dorn II Junichi Sadoshima Mark H. Ellisman Åsa B. Gustafsson
author_sort	Babette C. Hammerling
title	A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance
title_short	A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance
title_full	A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance
title_fullStr	A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance
title_full_unstemmed	A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance
title_sort	rab5 endosomal pathway mediates parkin-dependent mitochondrial clearance
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b90a7538f1694e4281da0c789cbd7c2c
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A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance

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