Histone deacetylase complexes promote trinucleotide repeat expansions.

Expansions of DNA trinucleotide repeats cause at least 17 inherited neurodegenerative diseases, such as Huntington's disease. Expansions can occur at frequencies approaching 100% in affected families and in transgenic mice, suggesting that specific cellular proteins actively promote (favor) exp...

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Autores principales: Kim Debacker, Aisling Frizzell, Olive Gleeson, Lucy Kirkham-McCarthy, Tony Mertz, Robert S Lahue
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/b927da874127465b9d9a9362fd86d0c4
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