Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2

The Polycomb repressive complexes PRC1 and PRC2 play a central role in developmental regulation of the genome in multicellular organisms. Here the authors describe how the PRC2 cofactor Jarid2 mediates the recruitment of the PRC2 complex to chromatin via interaction with H2AK119u1.

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Autores principales:	Sarah Cooper, Anne Grijzenhout, Elizabeth Underwood, Katia Ancelin, Tianyi Zhang, Tatyana B. Nesterova, Burcu Anil-Kirmizitas, Andrew Bassett, Susanne M. Kooistra, Karl Agger, Kristian Helin, Edith Heard, Neil Brockdorff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b92aed92ccad489c830eec2852858b92
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spelling	oai:doaj.org-article:b92aed92ccad489c830eec2852858b922021-12-02T15:34:33ZJarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC210.1038/ncomms136612041-1723https://doaj.org/article/b92aed92ccad489c830eec2852858b922016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13661https://doaj.org/toc/2041-1723The Polycomb repressive complexes PRC1 and PRC2 play a central role in developmental regulation of the genome in multicellular organisms. Here the authors describe how the PRC2 cofactor Jarid2 mediates the recruitment of the PRC2 complex to chromatin via interaction with H2AK119u1.Sarah CooperAnne GrijzenhoutElizabeth UnderwoodKatia AncelinTianyi ZhangTatyana B. NesterovaBurcu Anil-KirmizitasAndrew BassettSusanne M. KooistraKarl AggerKristian HelinEdith HeardNeil BrockdorffNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah Cooper Anne Grijzenhout Elizabeth Underwood Katia Ancelin Tianyi Zhang Tatyana B. Nesterova Burcu Anil-Kirmizitas Andrew Bassett Susanne M. Kooistra Karl Agger Kristian Helin Edith Heard Neil Brockdorff Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2
description	The Polycomb repressive complexes PRC1 and PRC2 play a central role in developmental regulation of the genome in multicellular organisms. Here the authors describe how the PRC2 cofactor Jarid2 mediates the recruitment of the PRC2 complex to chromatin via interaction with H2AK119u1.
format	article
author	Sarah Cooper Anne Grijzenhout Elizabeth Underwood Katia Ancelin Tianyi Zhang Tatyana B. Nesterova Burcu Anil-Kirmizitas Andrew Bassett Susanne M. Kooistra Karl Agger Kristian Helin Edith Heard Neil Brockdorff
author_facet	Sarah Cooper Anne Grijzenhout Elizabeth Underwood Katia Ancelin Tianyi Zhang Tatyana B. Nesterova Burcu Anil-Kirmizitas Andrew Bassett Susanne M. Kooistra Karl Agger Kristian Helin Edith Heard Neil Brockdorff
author_sort	Sarah Cooper
title	Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2
title_short	Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2
title_full	Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2
title_fullStr	Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2
title_full_unstemmed	Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2
title_sort	jarid2 binds mono-ubiquitylated h2a lysine 119 to mediate crosstalk between polycomb complexes prc1 and prc2
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b92aed92ccad489c830eec2852858b92
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Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2

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