High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation

Tran et al. combine high throughput sequencing, structural biology and computational simulation to determine the HLA allele and antibody-defined epitope frequencies in renal transplant patients and donors. These results demonstrate the feasibility of HLA epitope matching using data from a national t...

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Autores principales:	Jenny N. Tran, Oliver P. Günther, Karen R. Sherwood, Franz Fenninger, Lenka L. Allan, James Lan, Ruth Sapir-Pichhadze, Rene Duquesnoy, Frans Claas, Steven G. E. Marsh, W. Robert McMaster, Paul A. Keown, Genome Canada Transplant Consortium
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b93a195a6e5b4de3bc355588fb93e629
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spelling	oai:doaj.org-article:b93a195a6e5b4de3bc355588fb93e6292021-12-02T15:43:07ZHigh-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation10.1038/s42003-021-01989-32399-3642https://doaj.org/article/b93a195a6e5b4de3bc355588fb93e6292021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01989-3https://doaj.org/toc/2399-3642Tran et al. combine high throughput sequencing, structural biology and computational simulation to determine the HLA allele and antibody-defined epitope frequencies in renal transplant patients and donors. These results demonstrate the feasibility of HLA epitope matching using data from a national transplantation program.Jenny N. TranOliver P. GüntherKaren R. SherwoodFranz FenningerLenka L. AllanJames LanRuth Sapir-PichhadzeRene DuquesnoyFrans ClaasSteven G. E. MarshW. Robert McMasterPaul A. KeownGenome Canada Transplant ConsortiumNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jenny N. Tran Oliver P. Günther Karen R. Sherwood Franz Fenninger Lenka L. Allan James Lan Ruth Sapir-Pichhadze Rene Duquesnoy Frans Claas Steven G. E. Marsh W. Robert McMaster Paul A. Keown Genome Canada Transplant Consortium High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation
description	Tran et al. combine high throughput sequencing, structural biology and computational simulation to determine the HLA allele and antibody-defined epitope frequencies in renal transplant patients and donors. These results demonstrate the feasibility of HLA epitope matching using data from a national transplantation program.
format	article
author	Jenny N. Tran Oliver P. Günther Karen R. Sherwood Franz Fenninger Lenka L. Allan James Lan Ruth Sapir-Pichhadze Rene Duquesnoy Frans Claas Steven G. E. Marsh W. Robert McMaster Paul A. Keown Genome Canada Transplant Consortium
author_facet	Jenny N. Tran Oliver P. Günther Karen R. Sherwood Franz Fenninger Lenka L. Allan James Lan Ruth Sapir-Pichhadze Rene Duquesnoy Frans Claas Steven G. E. Marsh W. Robert McMaster Paul A. Keown Genome Canada Transplant Consortium
author_sort	Jenny N. Tran
title	High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation
title_short	High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation
title_full	High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation
title_fullStr	High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation
title_full_unstemmed	High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation
title_sort	high-throughput sequencing defines donor and recipient hla b-cell epitope frequencies for prospective matching in transplantation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b93a195a6e5b4de3bc355588fb93e629
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High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation

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