Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues

The necroptotic cell death pathway involves signaling through pseudokinases. Here the authors define the structural determinants of species specificity in necroptosis signaling mediated by the essential necroptotic effector pseudokinase, Mixed Lineage Kinase Domain-Like (MLKL).

Guardado en:

Detalles Bibliográficos
Autores principales:	Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Wayland Yeung, Diane Coursier, Richard W. Birkinshaw, Jarrod J. Sandow, Wil I. L. Lehmann, Lung-Yu Liang, Isabelle S. Lucet, James D. Chalmers, Wayne M. Patrick, Natarajan Kannan, Emma J. Petrie, Peter E. Czabotar, James M. Murphy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b93b0f25bce74b3387360f9736d00ebc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b93b0f25bce74b3387360f9736d00ebc
record_format	dspace
spelling	oai:doaj.org-article:b93b0f25bce74b3387360f9736d00ebc2021-12-02T17:40:29ZDistinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues10.1038/s41467-020-16823-32041-1723https://doaj.org/article/b93b0f25bce74b3387360f9736d00ebc2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16823-3https://doaj.org/toc/2041-1723The necroptotic cell death pathway involves signaling through pseudokinases. Here the authors define the structural determinants of species specificity in necroptosis signaling mediated by the essential necroptotic effector pseudokinase, Mixed Lineage Kinase Domain-Like (MLKL).Katherine A. DaviesCheree FitzgibbonSamuel N. YoungSarah E. GarnishWayland YeungDiane CoursierRichard W. BirkinshawJarrod J. SandowWil I. L. LehmannLung-Yu LiangIsabelle S. LucetJames D. ChalmersWayne M. PatrickNatarajan KannanEmma J. PetriePeter E. CzabotarJames M. MurphyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katherine A. Davies Cheree Fitzgibbon Samuel N. Young Sarah E. Garnish Wayland Yeung Diane Coursier Richard W. Birkinshaw Jarrod J. Sandow Wil I. L. Lehmann Lung-Yu Liang Isabelle S. Lucet James D. Chalmers Wayne M. Patrick Natarajan Kannan Emma J. Petrie Peter E. Czabotar James M. Murphy Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
description	The necroptotic cell death pathway involves signaling through pseudokinases. Here the authors define the structural determinants of species specificity in necroptosis signaling mediated by the essential necroptotic effector pseudokinase, Mixed Lineage Kinase Domain-Like (MLKL).
format	article
author	Katherine A. Davies Cheree Fitzgibbon Samuel N. Young Sarah E. Garnish Wayland Yeung Diane Coursier Richard W. Birkinshaw Jarrod J. Sandow Wil I. L. Lehmann Lung-Yu Liang Isabelle S. Lucet James D. Chalmers Wayne M. Patrick Natarajan Kannan Emma J. Petrie Peter E. Czabotar James M. Murphy
author_facet	Katherine A. Davies Cheree Fitzgibbon Samuel N. Young Sarah E. Garnish Wayland Yeung Diane Coursier Richard W. Birkinshaw Jarrod J. Sandow Wil I. L. Lehmann Lung-Yu Liang Isabelle S. Lucet James D. Chalmers Wayne M. Patrick Natarajan Kannan Emma J. Petrie Peter E. Czabotar James M. Murphy
author_sort	Katherine A. Davies
title	Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
title_short	Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
title_full	Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
title_fullStr	Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
title_full_unstemmed	Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
title_sort	distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate mlkl orthologues
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b93b0f25bce74b3387360f9736d00ebc
work_keys_str_mv	AT katherineadavies distinctpseudokinasedomainconformationsunderliedivergentactivationmechanismsamongvertebratemlklorthologues AT chereefitzgibbon distinctpseudokinasedomainconformationsunderliedivergentactivationmechanismsamongvertebratemlklorthologues AT samuelnyoung distinctpseudokinasedomainconformationsunderliedivergentactivationmechanismsamongvertebratemlklorthologues AT sarahegarnish distinctpseudokinasedomainconformationsunderliedivergentactivationmechanismsamongvertebratemlklorthologues AT waylandyeung distinctpseudokinasedomainconformationsunderliedivergentactivationmechanismsamongvertebratemlklorthologues AT dianecoursier distinctpseudokinasedomainconformationsunderliedivergentactivationmechanismsamongvertebratemlklorthologues AT richardwbirkinshaw distinctpseudokinasedomainconformationsunderliedivergentactivationmechanismsamongvertebratemlklorthologues AT jarrodjsandow distinctpseudokinasedomainconformationsunderliedivergentactivationmechanismsamongvertebratemlklorthologues AT wilillehmann distinctpseudokinasedomainconformationsunderliedivergentactivationmechanismsamongvertebratemlklorthologues AT lungyuliang distinctpseudokinasedomainconformationsunderliedivergentactivationmechanismsamongvertebratemlklorthologues AT isabelleslucet distinctpseudokinasedomainconformationsunderliedivergentactivationmechanismsamongvertebratemlklorthologues AT jamesdchalmers distinctpseudokinasedomainconformationsunderliedivergentactivationmechanismsamongvertebratemlklorthologues AT waynempatrick distinctpseudokinasedomainconformationsunderliedivergentactivationmechanismsamongvertebratemlklorthologues AT natarajankannan distinctpseudokinasedomainconformationsunderliedivergentactivationmechanismsamongvertebratemlklorthologues AT emmajpetrie distinctpseudokinasedomainconformationsunderliedivergentactivationmechanismsamongvertebratemlklorthologues AT petereczabotar distinctpseudokinasedomainconformationsunderliedivergentactivationmechanismsamongvertebratemlklorthologues AT jamesmmurphy distinctpseudokinasedomainconformationsunderliedivergentactivationmechanismsamongvertebratemlklorthologues
_version_	1718379785701294080

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues

Ejemplares similares