Conversion from Positive to Negative EGFR Mutation due to Clonal Selection during Long-Term Treatment with Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors: A Case Report

A 77-year-old woman with postoperative recurrent non-small cell lung adenocarcinoma, which exhibited an epidermal growth factor receptor (EGFR) L858R mutation, was treated with gefitinib and erlotinib. Seven years after the start of treatment, the patient experienced a recurrence of malignant pleura...

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Autores principales: Masatomo Ueda, Masashi Namba, Kentaro Tokumo, Tadashi Senoo, Wataru Okamoto, Masami Yamauchi, Noboru Hattori, Kazuhiko Sugiyama
Formato: article
Lenguaje:EN
Publicado: Karger Publishers 2021
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Acceso en línea:https://doaj.org/article/b9403e50a0b0414485fc95a2df433686
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